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Table 2 C M-specific genes obtained by use of the Welch t test and a Bonferroni correction

From: Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice

IDa

Cluster

Symbolb

Name

Chrc

Welch t testd

BG083931

A

Slc25a11

Solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11

11

D2

...

...

718084

A

Dfy

Duffy blood group

1

D2

...

...

BG064714

A

Slc3a2

Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

19

D2

...

...

573549

A

Mrps34

Mitochondrial ribosomal protein S34

17

D2

D5

...

641184

A

Cdc37l1

Cell division cycle 37 homolog (S. cerevisiae)-like

19

D2

D5e

...

641058

A

Nfkbia

Nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha

12

...

D5

D7

BG086014

A

Hmgn1

High mobility group nucleosomal binding domain 1

16

D2

D5

...

639606

A

E030041M21Rik

RIKEN cDNA E030041M21 gene

10

D2f

D5

...

636468

A

Epb4.1l3

Erythrocyte protein band 4.1-like 3

17

...

D5

...

BG084377

A

Stat3

Signal transducer and activator of transcription 3

11

D2

...

...

582660

A

Tagap1

T-cell activation GTPase activating protein 1

17

D2

D5

D7

573243

B

Ddi2

DNA-damage inducible protein 2

4

...

D5

...

BG071164

B

2310008M10Rik

RIKEN cDNA 2310008M10 gene

3

D2

...

D7

BG070859

B

Nipbl

Nipped-B homolog (Drosophila)

15

...

D5e

D7

639002

B

Mlx

MAX-like protein X

11

D2

D5

D7

BG072955

B

Myo5a

Myosin Va

9

...

...

D7

575433

B

Ptger1

Prostaglandin E receptor 1 (subtype EP1), 42 kD

8

...

...

D7

BG087138

B

Itsn2

Intersectin 2

12

D2

...

D7

BG078795

B

Hspa5

Heat shock 70 kD protein 5 (glucose-regulated protein)

2

...

...

D7

BG064608

B

Calr

Calreticulin

8

...

...

D7

BG087169

B

P4hb

Protein disulfide isomerase associated 6

12

...

...

D7

764825

B

Reln

Reelin

5

D2

...

...

1263789

B

Cxcl12

Chemokine (C-X-C motif) ligand 12

6

D2

...

...

441212

B

Atp6v1g2

ATPase, H+ transporting, lysosomal 13 kD, V1 subunit G isoform 2

17

D2

...

...

577991

B

Zdhhc6

Zinc finger, DHHC domain containing 6

19

...

D5

...

1263101

B

Hmgcs1

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

13

...

D5

...

573257

B

Pcgf3

Polycomb group ring finger 3

5

...

...

D7

436894

B

Fabp7

Fatty acid binding protein 7, brain

10

...

...

D7

BG076809

C

Rps18

Ribosomal protein S18

17

D2

...

...

BG085025

C

Dab1

Disabled homolog 1 (Drosophila)

4

...

D5

...

718873

C

S100a10

S100 calcium binding protein A10 (calpactin)

3

D2

D5

...

576647

C

Chchd1

Coiled-coil-helix-coiled-coil-helix domain containing 1

14

D2

D5

...

BG063799

C

Ak3l1

Adenylate kinase 3 alpha-like 1

4

...

...

D7

BG077012

C

Cdc6

Cell division cycle 6 homolog (S. cerevisiae)

11

D2

D5

...

BG077054

C

Ncbp2

Nuclear cap binding protein subunit 2, 20 kDa

16

D2

...

...

BG062969

C

Hnrpdl

Heterogeneous nuclear ribonucleoprotein D-like

5

D2

...

...

576635

C

Vcam1

Vascular cell adhesion molecule 1

3

D2

...

...

402711

C

Crybb1

Crystallin, beta B1

5

...

...

D7

BG080965

C

Prkcbp1

Protein kinase C binding protein 1

2

...

...

D7

BG074422

C

Itgb1

Integrin beta 1 (fibronectin receptor beta)

8

...

D5

...

BG084605

C

Bpgm

2,3-bisphosphoglycerate mutase

6

D2

...

...

BG078316

C

Sfxn1

Sideroflexin 1

13

...

...

D7

BG076061

C

Lyar

Ly1 antibody reactive clone

5

...

...

D7

BG077320

C

Mrps10

Mitochondrial ribosomal protein S10

17

D2

...

...

BG077670

C

Gnai2

Guanine nucleotide binding protein, alpha inhibiting 2

9

D2

...

D7

406838

C

Foxo3a

Forkhead box O3a

10

...

...

D7

BG072299

C

Ramp2

Receptor (calcitonin) activity modifying protein 2

19

...

...

D7

1224916

C

Atxn7

Ataxin 7

14

D2

...

...

1395654

C

Batf

Basic leucine zipper transcription factor, ATF-like

12

D2

D5

...

BG087349

C

Aldh1b1

Aldehyde dehydrogenase 1 family, member B1

4

D2

...

...

596637

C

Stab2

Stabilin 2

10

D2

...

...

596064

C

Cd5

CD5 antigen

19

D2

...

...

573880

C

Nfyc

Nuclear transcription factor-Y gamma

4

D2

...

...

1226020

C

Unknown

Unknown

...

D2

...

D7

400157

C

Uqcrq

Ubiquinol-cytochrome c reductase binding protein

11

...

...

D7

BG086406

C

Agtr2

Angiotensin II receptor, type 2

X

...

...

D7

582804

C

Cys1

Cystin 1

12

...

D5

...

576480

C

Igf2bp3

Insulin-like growth factor 2 mRNA binding protein 3

6

D2

D5

...

464586

C

Srr

Serine racemase

11

D2

...

...

575610

C

2700085E05Rik

RIKEN cDNA 2700085E05 gene

11

D2

...

...

575040

C

Sel1h

Sel1 (suppressor of lin-12) 1 homolog (C. elegans)

12

D2

...

...

BG087165

C

Herc4

Hect domain and RLD 4

10

D2

...

D7

BG073254

C

Rbmxrt

RNA binding motif protein, X chromosome retrogene

8

D2

...

...

BG073981

C

Gtpbp8

GTP-binding protein 8 (putative)

16

...

D5

D7

573285

C

Lrriq2

Leucine-rich repeats and IQ motif containing 2

16

D2

...

...

372621

C

Icam5

Intercellular adhesion molecule 5, telencephalin

9

...

...

D7

1428894

C

Ptpns1

Protein tyrosine phosphatase, non-receptor type substrate 1

2

...

...

D7

BG076772

C

Gpd2

Glycerol phosphate dehydrogenase 2, mitochondrial

2

...

...

D7

752149

C

Stk16

Serine/threonine kinase 16

1

...

D5

D7

573328

C

Thrsp

Thyroid hormone responsive SPOT14 homolog (Rattus)

7

...

D5

D7

BG087431

C

Sec31a

SEC31 homolog A (S. cerevisiae)

5

D2

...

...

BG087401

C

Brd7

Bromodomain-containing 7

8

D2

D5

D7

1361813

C

Mmachc

Methylmalonic aciduria cblC type, with homocystinuria

4

D2

...

...

BG076501

C

Sfrs6

Splicing factor, arginine/serine-rich 6

2

...

...

D7

1243669

C

Aldoa

Aldolase 1, A isoform

7

...

D5

...

476643

C

Sez6l

Seizure related 6 homolog like

5

D2

...

...

BG075757

C

Cd81

CD 81 antigen

7

D2

...

...

574496

C

Usp19

Ubiquitin specific peptidase 19

9

D2

D5f

...

BG065688

C

Uba52

Ubiquitin A-52 residue ribosomal protein fusion product 1

8

...

...

D7

BG078688

C

Dtnb

Dystrobrevin, beta

12

...

...

D7

BG086001

C

Sv2a

Synaptic vesicle glycoprotein 2 a

3

...

...

D7

BG073641

C

Rpl27

Ribosomal protein L27

11

D2

...

...

BG087402

C

Hnrpu

Heterogeneous nuclear ribonucleoprotein U

1

...

...

D7

595925

C

Sell

Selectin, lymphocyte

1

D2

...

...

1345776

C

Rbm14

RNA binding motif protein 14

19

...

...

D7

BG077327

C

Gins4

GINS complex subunit 4 (Sld5 homolog)

8

D2

D5

...

387319

C

Zfp346

Zinc finger protein 346

13

D2e

...

D7

AW546565

C

Exosc7

Exosome component 7

9

...

...

D7

BG072456

C

Pih1d1

PIH1 domain containing 1

7

...

...

D7

BG074521

C

Npm1

Nucleophosmin 1

11

D2

...

...

BG085278

C

Rpl22

Ribosomal protein L22

4

D2e

D5

D7

1445843

C

Ahcyl1

S-adenosylhomocysteine hydrolase-like 1

3

D2

...

D7

BG087592

C

Fbxw7

F-box and WD-40 domain protein 7, archipelago homolog (Drosophila)

3

D2

D5e

D7

BG064589

C

Atp6v1a1

ATPase, H+ transporting, lysosomal 70 kD, V1 subunit A, isoform 1

16

D2

...

D7

441227

C

Abtb1

Ankyrin repeat and BTB (POZ) domain containing 1

6

D2

D5

...

386911

C

Trim29

Tripartite motif protein 29

9

...

...

D7

BG087083

C

Serinc3

Serine incorporator 3

2

D2

...

...

372340

C

Myod1

Myogenic differentiation 1

7

D2

...

...

BG081915

C

Ube3a

Ubiquitin protein ligase E3A

7

D2

D5

...

573124

C

Mrrf

Mitochondrial ribosome recycling factor

2

D2

D5

...

573230

C

4930455C21Rik

RIKEN cDNA 4930455C21 gene

16

...

...

D7

1243507

C

Unknown

Unknown

...

D2

D5

D7

BG065706

C

Rabl3

RAB, member of RAS oncogene family-like 3

16

...

...

D7

BG078879

C

Cox4i1

Cytochrome c oxidase, subunit IVa

8

D2

...

...

BG088493

C

Ptplad1

Protein tyrosine phosphatase-like A domain containing 1

9

...

...

D7

1378435

C

Acad8

acyl-Coenzyme A dehydrogenase family, member 8

9

D2

...

...

1429286

C

1600002K03Rik

RIKEN cDNA 1600002K03 gene

10

...

D5

...

BG078872

C

Pfkfb2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

1

...

D5

...

420477

C

Col13a1

Procollagen, type XIII, alpha 1

10

D2

...

...

402631

C

Crebl1

cAMP responsive element binding protein-like 1

17

...

D5

...

1445700

C

4930506M07Rik

RIKEN cDNA 4930506M07 gene

19

D2e

...

D7

575274

C

Nvl

Nuclear VCP-like

1

D2

...

D7

574369

C

Il4

Interleukin 4

11

D2

D5

D7

BG071511

C

Suclg1

Succinate-CoA ligase, GDP-forming, alpha subunit

6

D2

...

D7

573178

C

Igfbp7

Insulin-like growth factor binding protein 7

5

...

D5

...

574126

C

Dnaja3

DnaJ (Hsp40) homolog, subfamily A, member 3

16

D2

...

D7

1226596

C

Fem1c

fem-1 homolog c (C.elegans)

18

D2e

D5

D7

BG087153

C

Bckdha

Branched chain ketoacid dehydrogenase E1, alpha polypeptide

7

D2e

D5

D7

402019

C

Golga7

Golgi autoantigen, golgin subfamily a, 7

8

D2e

...

D7

574168

C

Prosc

Proline synthetase co-transcribed

8

D2e

D5

D7

BG073436

C

Atp5b

ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

10

D2e

D5

D7

574027

C

Med19

Mediator of RNA polymerase II transcription, subunit 19 homolog (yeast)

2

D2

D5

...

1243989

C

Mfhas1

Malignant fibrous histiocytoma amplified sequence 1

8

D2

D5

D7

373233

C

Itgb5

Integrin beta 5

16

...

...

D7

BG085816

C

Spna2

Alpha-spectrin 2, brain

2

...

...

D7

1446130

C

2410166I05Rik

RIKEN cDNA 2410166I05 gene

4

D2

...

D7

1263575

C

Stard4

StAR-related lipid transfer (START) domain containing 4

18

D2

D5

...

1852943

C

Ankrd17

Gene trap ankyrin repeat

5

...

...

D7

389112

C

Palm

Paralemmin

10

...

...

D7

619816

C

Smad5

MAD homolog 5 (Drosophila)

13

...

...

D7

641790

C

BC023814

cDNA sequence BC023814

3

...

...

D7

1329743

C

S3–12

Plasma membrane associated protein, S3–12

17

...

...

D7

653795

C

Il4ra

Interleukin 4 receptor, alpha

7

D2

...

D7

640435

C

Igsf3

Immunoglobulin superfamily, member 3

3

...

...

D7

387990

C

0610040D20Rik

RIKEN cDNA 0610040D20 gene

9

D2

D5

...

BG075962

C

Peci

Peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase

13

D2

...

...

BG086412

C

Rpl31

Ribosomal protein L31

1

D2

...

...

BG075914

C

Rps9

Ribosomal protein S9

7

D2

...

...

639852

C

Bsg

Basigin

10

D2

...

...

573106

C

Slc25a1

Solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

16

D2

...

D7

574123

C

Suds3

Suppressor of defective silencing 3 homolog (S. cerevisiae)

5

D2

...

...

BG088819

C

1810043G02Rik

RIKEN cDNA 1810043G02 gene

10

D2

...

...

BG088858

C

1810044A24Rik

RIKEN cDNA 1810044A24 gene

15

D2

D5

D7

BG078275

C

C230096C10Rik

RIKEN cDNA C230096C10 gene

4

D2

...

D7

573120

C

2310035K24Rik

RIKEN cDNA 2310035K24 gene

2

D2

D5

...

BG076791

C

Eef1d

Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

15

D2

...

...

BG087946

C

Ubtf

Transcription factor UBF

11

D2

D5f

D7

372316

C

Ly6h

Lymphocyte antigen 6 complex, locus H

15

D2

...

D7

1243611

C

Tmem23

Transmembrane protein 23

19

D2

D5

D7

574299

C

2700059D21Rik

RIKEN cDNA 2700059D21 gene

4

...

D5

D7

BG064820

C

Sae1

SUMO1 activating enzyme subunit 1

7

D2

...

...

BG071827

C

Ppm1b

Protein phosphatase 1B, magnesium dependent, beta isoform

17

D2

D5f

...

BG086606

C

Txndc12

Thioredoxin domain containing 12 (endoplasmic reticulum)

4

D2

...

...

BG085962

C

Gsn

Gelsolin

2

D2

...

...

575308

C

Dus3l

Dihydrouridine synthase 3-like (S. cerevisiae)

17

...

...

D7

573228

C

Fyco1

FYVE and coiled-coil domain containing 1

9

D2

D5

...

BG081532

C

Sfpq

Splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

4

D2

D5f

D7f

BG072614

C

Rps16

Ribosomal protein S16

7

D2

...

...

BG078928

C

Stmn3

Stathmin-like 3

2

...

...

D7

1226306

C

Cd274

CD274 antigen

19

D2

D5

...

AW544628

C

Itgb1

Integrin beta 1 (fibronectin receptor beta)

8

D2

...

D7

BG087322

C

Rps6ka2

Ribosomal protein S6 kinase, 90 kD, polypeptide 2

17

D2

D5

...

641964

C

Cd4

CD4 antigen

6

D2

D5f

...

BG071505

C

Slc28a3

Solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

13

D2

D5

...

BG088775

C

Znhit3

Zinc finger, HIT type 3

11

D2

D5

...

BG069977

C

Pmm1

Phosphomannomutase 1

15

D2

D5

...

574022

E

1200015M12Rik

RIKEN cDNA 1200015M12 gene

3

D2

...

...

BG086286

E

Cirbp

Cold inducible RNA binding protein

10

D2

...

...

598493

E

Ifit3

Interferon-induced protein with tetratricopeptide repeats 3

19

D2

D5

...

617022

"

"

"

"

"

"

"

1329893

E

2600010E01Rik

RIKEN cDNA 2600010E01 gene

2

...

...

D7

BG076479

E

Ctla2a

Cytotoxic T lymphocyte-associated protein 2 alpha

13

...

D5f

D7

BG088327

E

Sf3b1

Splicing factor 3b, subunit 1, 155 kDa

1

...

D5

...

BG076355

E

Stat3

Signal transducer and activator of transcription 3

11

D2

...

...

643048

E

Gbp6

Guanylate binding protein 6

3

...

D5

...

638199

E

H2-T22

Histocompatibility 2, T region locus 22

17

D2

D5f

...

638232

E

Jundm2

Jun dimerization protein 2

12

D2

D5

...

1394984

E

Rps14

Ribosomal protein S14

18

...

...

D7

  1. a Clone ID or GenBank accession no.
  2. b The genes Il4ra and Ifit3 were duplicates (the same clone for the gene Il4ra and two different clones for the gene Ifit3). Thus, there were 177 genes identified.
  3. c Chromosomal localization.
  4. d The days for which the Welch t test was significant (<0.0001) after Bonferroni correction are mentioned.
  5. e Significant difference was observed only between BALB/c and C57BL/6.
  6. f Significant difference was observed only between BALB/c and CBA/J.