The plasticizer butyl benzyl phthalate induces genomic changes in rat mammary gland after neonatal/prepubertal exposure

Table 1 Parameters for post-natal maturation and development

	21 days	35 days	50 days	100 days
Uterine weight (mg)
Control	30.0 ± 1.4	167 ± 27	288 ± 17	409 ± 20
BBP	36.0 ± 2.1	207 ± 16	319 ± 24	429 ± 19
Uterine weight/BW (mg/g)
Control	0.51 ± 0.03	1.27 ± 0.20	1.48 ± 0.08	1.31 ± 0.07
BBP	0.65 ± 0.04*	1.56 ± 0.13	1.65 ± 0.10	1.39 ± 0.04
Development of the mammary gland
Number of TEB
Control	39.5 ± 2.32	30.4 ± 5.22	18.3 ± 3.71	0.22 ± 0.22
BBP	40.0 ± 4.68	30.2 ± 5.78	22.7 ± 3.16	0.40 ± 0.40
Number of TD
Control	24.5 ± 1.65	38.2 ± 4.17	41.1 ± 3.40	57.3 ± 5.21
BBP	25.9 ± 2.52	33.5 ± 4.08	46.6 ± 7.31	61.8 ± 5.41
Number of AB
Control	8.0 ± 1.87	14.9 ± 1.08	10.1 ± 2.04	0.2 ± 0.22
BBP	5.7 ± 1.20	13.7 ± 1.65	8.9 ± 1.05	0.2 ± 0.20
Number of Lob1
Control	0	30.1 ± 4.58	43.4 ± 5.74	42.7 ± 6.41
BBP	0	39.0 ± 7.29	42.9 ± 4.43	46.2 ± 8.64

Maturation parameters and histoarchitectural study of the mammary gland for controls and rats exposed neonatally/prepubertally to BBP. Results are indicated as mean ± SEM. BW: body weight. *: significantly different compared to control group (p < 0.05).

ISSN: 1471-2164