Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells

BMC Genomics

Table 3 Enriched TFBS In Genes Differentially Expressed in Stat3^Δ/Δ mice

TFBS	Count (Diff_Gene)	Frequency (Diff_Gene)	Count (background)	Frequency (background)	P-Value	Q-Value
V$STAT	863	0.97	786	0.79	4.93E-59	2.29E-56
V$EGRF	850	0.96	757	0.76	2.92E-57	1.35E-54
V$AHRR	706	0.80	544	0.54	4.04E-53	1.87E-50
V$SP1F	857	0.97	789	0.79	2.15E-49	9.96E-47
V$ZF5F	502	0.57	321	0.32	2.18E-48	1.01E-45
V$E2FF	850	0.96	778	0.78	1.30E-47	6.03E-45
V$HIFF	564	0.64	439	0.44	4.66E-30	2.16E-27
V$SREB	513	0.58	425	0.42	2.76E-17	1.28E-14
V$AP2F	492	0.56	420	0.42	4.93E-15	2.29E-12

Note: promoter sequence (-2000 – 0 bps) from 886 out of 1105 differentially genes were available for analysis. The P-Value is calculated using binomial distribution probability. 5 random sets of 1000 mouse gene -2kb promoter regions were used to calculate the background frequency. The Q-Value is calculated using single-step Bonferroni adjustment to control for the multiple comparison effect.

ISSN: 1471-2164