Figure 4
From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis
Top ten genes differentially expressed between unfused coronal, lambdoid and sagittal sutures. Genes commonly identified to be differentially expressed (P < 0.01) in unfused coronal and lambdoid sutures compared to unfused sagittal sutures, using two methods of microarray data analysis: 3-way and matched-pairs. Eight genes (FGR, RASGRP2, IGLL1, IL17R, NCF1, APOC1, TACC3, and MKI67) have higher expression in unfused sagittal sutures and two (HLF and SLC7A6) have lower expression compared to unfused coronal and lambdoid sutures. HLF shows a gradient of expression, highest in lambdoid, then coronal, then sagittal sutures, whereas the other genes show similar expression in coronal and lambdoid sutures. For each gene listed, sutures are in patient order: coronal (#36, #46, #50, #58), lambdoid (#46, #58), sagittal (#36, #58).