Table 3 Selection of genes with fold change between unfused and fused sutures and between each unfused suture site.
From: Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis
Gene Name | Affymetrix ID | Description | Fold U-F | P-value U-F | Unfused Lambdoid | Unfused Coronal | Unfused Sagittal |
|---|---|---|---|---|---|---|---|
Signalling | |||||||
   ANGPTNL2 | 213004_at | angiopoietin-like 2 | 6.67 | 0.024 | 1.00 | -1.45 | -2.87 |
   EGFR | 201983_s_at | epidermal growth factor receptor | 2.71 | 0.038 | 1.00 | 1.02 | 1.20 |
   EPHA3 | 206071_s_at | EPH receptor A3 | 2.92 | 0.480 | 1.00 | -2.06 | -5.33 |
   EPHA4 | 206114_at | EPH receptor A4 | 2.75 | 0.173 | 1.00 | -1.19 | -1.60 |
   EPHB2 | 209589_s_at | EPH receptor B2 | 2.39 | 0.093 | 1.00 | 1.22 | -1.12 |
   FGFR2 | 208228_s_at | fibroblast growth factor receptor 2 | 3.36 | 0.294 | 1.00 | -1.42 | -3.72 |
   FZD1 | 204451_at | frizzled homolog 1 (Drosophila) | 2.13 | 0.326 | 1.00 | -1.08 | -2.41 |
   IL11RA | 204773_at | interleukin 11 receptor, alpha | 5.90 | 0.003 | 1.00 | 1.49 | 1.32 |
   TGFB2 | 209909_s_at | transforming growth factor, beta 2 | 3.76 | 0.096 | 1.00 | -1.01 | -2.08 |
   FGFR1 | 222164_at | fibroblast growth factor receptor 1 | 1.23 | 0.480 | 1.00 | -1.29 | 1.12 |
   FGFR3 | 204379_s_at | fibroblast growth factor receptor 3 | 1.42 | 0.480 | 1.00 | 1.23 | 1.33 |
   WNT5A | 205990_s_at | wingless-type MMTV integration site family, member 5A | 1.24 | 0.857 | 1.00 | -1.03 | -5.18 |
   IL17R | 205707_at | interleukin 17 receptor | -2.67 | 0.480 | 1.00 | -1.25 | 3.35 |
   OLFM4 | 212768_s_at | olfactomedin 4 | -6.69 | 0.480 | 1.00 | -2.15 | 6.77 |
   WIF1 | 204712_at | WNT inhibitory factor 1 | -3.19 | 0.480 | 1.00 | -1.27 | 5.37 |
Structural | |||||||
   COL2A1 | 213492_at | collagen, type II, alpha 1 (primary osteoarthritis) | 7.21 | 0.390 | 1.00 | -20.66 | -3.84 |
   COL3A1 | 215077_at | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV) | 6.32 | 0.072 | 1.00 | 1.24 | -3.84 |
   COL8A2 | 221900_at | collagen, type VIII, alpha 2 | 11.49 | 0.092 | 1.00 | -1.23 | -12.73 |
   COL10A1 | 217428_s_at | collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) | 14.65 | 0.407 | 1.00 | -41.66 | -17.28 |
   FBLN1 | 202995_s_at | fibulin 1 | 12.88 | 0.025 | 1.00 | -1.39 | -1.92 |
   FMOD | 202709_at | fibromodulin | 5.41 | 0.024 | 1.00 | -1.09 | -1.70 |
   NELL2 | 203413_at | NEL-like 2 (chicken) | 6.40 | 0.270 | 1.00 | -4.21 | -3.01 |
   PRELP | 204223_at | proline arginine-rich end leucine-rich repeat protein | 10.65 | 0.009 | 1.00 | 1.20 | -1.31 |
   THBS2 | 203083_at | thrombospondin 2 | 6.62 | 0.069 | 1.00 | -1.26 | -2.47 |
   COL1A2 | 202404_s_at | collagen, type I, alpha 2 | 1.05 | 0.480 | 1.00 | -1.01 | -1.06 |
   CORO1A | 209083_at | coronin, actin binding protein, 1A | -5.08 | 0.480 | 1.00 | -1.05 | 11.73 |
Transcription | |||||||
   BHLH3 | 221530_s_at | basic helix-loop-helix domain containing, class B, 3 | 5.95 | 0.093 | 1.00 | -2.23 | -4.76 |
   CART1 | 206837_at | cartilage paired-class homeoprotein 1 | 2.06 | 0.533 | 1.00 | 16.21 | 2.38 |
   HLF | 204753_s_at | hepatic leukemia factor | 3.54 | 0.210 | 1.00 | -2.55 | -6.81 |
   JUN | 201465_s_at | v-jun sarcoma virus 17 oncogene homolog (avian) | 4.41 | 0.161 | 1.00 | 3.14 | 2.50 |
   PITX2 | 207558_s_at | paired-like homeodomain transcription factor 2 | 3.45 | 0.279 | 1.00 | 1.63 | -2.08 |
   SIX2 | 206510_at | sine oculis homeobox homolog 2 (Drosophila) | 2.72 | 0.136 | 1.00 | -1.09 | -1.70 |
   FOS | 209189_at | v-fos FBJ murine osteosarcoma viral oncogene homolog | 1.40 | 0.745 | 1.00 | 14.96 | 4.13 |
   FOSB | 202768_at | FBJ murine osteosarcoma viral oncogene homolog B | 1.83 | 0.695 | 1.00 | 54.37 | 20.22 |
   FOXD1 | 206307_s_at | forkhead box D1 | 1.49 | 0.499 | 1.00 | -4.71 | -5.17 |
   JUNB | 201473_at | jun B proto-oncogene | 1.28 | 0.703 | 1.00 | 3.61 | 2.95 |
   MEOX2 | 206201_s_at | mesenchyme homeo box 2 (growth arrest-specific homeo box) | 1.66 | 0.495 | 1.00 | -3.99 | -7.74 |
   MSX2 | 210319_x_at | msh homeo box homolog 2 (Drosophila) | 1.95 | 0.464 | 1.00 | -1.14 | -2.23 |
   TWIST1 | 213943_at | twist homolog 1 (Saethre-Chotzen syndrome) | 1.50 | 0.476 | 1.00 | -1.20 | -1.27 |
   LHX6 | 219884_at | LIM homeobox 6 | -1.80 | 0.050 | 1.00 | -1.07 | -1.03 |
   SHOX2 | 210135_s_at | short stature homeobox 2 | -3.44 | 0.480 | 1.00 | -1.00 | 4.50 |
   PAX5 | 221969_at | paired box gene 5 (B-cell lineage specific activator) | -4.20 | 0.480 | 1.00 | -1.69 | 6.25 |
Catalytic Activity | |||||||
   ROR1 | 205805_s_at | receptor tyrosine kinase-like orphan receptor 1 | 2.26 | 0.095 | 1.00 | 1.21 | -1.14 |
   HDHD1A | 203974_at | haloacid dehalogenase-like hydrolase domain containing 1A | -1.78 | 0.018 | 1.00 | 1.05 | 1.05 |
   ALOX5 | 204446_s_at | arachidonate 5-lipoxygenase | -5.55 | 0.480 | 1.00 | -1.30 | 6.76 |
   ANXA3 | 209369_at | annexin A3 | -7.17 | 0.480 | 1.00 | -1.30 | 6.76 |
Transporter | |||||||
   C1QTNF3 | 220988_s_at | C1q and tumor necrosis factor related protein 3 | 20.25 | 0.007 | 1.00 | -1.52 | -4.92 |
   RBP4 | 219140_s_at | retinol binding protein 4 (plasma) KIAA1922 | 37.38 | 0.003 | 1.00 | -1.35 | -2.53 |
   APOC1 | 204416_x_at | apolipoprotein C-I | -2.01 | 0.480 | 1.00 | 1.08 | 5.06 |
Binding | |||||||
   AGC1 | 217161_x_at | aggrecan 1 (chondroitin sulfate proteoglycan 1) | 6.16 | 0.024 | 1.00 | -1.25 | -1.56 |
   CCND1 | 208711_s_at | cyclin D1 | 2.13 | 0.449 | 1.00 | 1.38 | 2.24 |
   GPC3 | 209220_at | glypican 3 | 7.13 | 0.050 | 1.00 | 1.26 | -3.34 |
   HAPLN1 | 205523_at | hyaluronan and proteoglycan link protein 1 | 7.10 | 0.050 | 1.00 | -1.96 | -4.01 |
   INHBA | 210511_s_at | inhibin, beta A (activin A, activin AB alpha polypeptide) | 6.94 | 0.006 | 1.00 | -1.36 | -3.03 |
   MFAP4 | 212713_at | microfibrillar-associated protein 4 | 16.50 | 0.001 | 1.00 | 1.32 | -1.86 |
   OGN | 218730_s_at | osteoglycin (osteoinductive factor, mimecan) | 5.71 | 0.166 | 1.00 | -1.41 | -4.65 |
   POSTN | 214981_at | periostin (osteoblast specific factor 2) | 5.87 | 0.101 | 1.00 | -1.16 | -1.60 |
   PTN | 209466_x_at | pleiotrophin (osteoblast specific factor 1) | 6.25 | 0.031 | 1.00 | -1.14 | -1.78 |
   S100A10 | 200872_at | S100 calcium binding protein A10 (annexin II ligand) | 2.01 | 0.096 | 1.00 | -1.04 | -1.60 |
   CCND3 | 201700_at | cyclin D3 | -2.60 | 0.480 | 1.00 | -1.00 | 3.62 |
   FCN1 | 205237_at | ficolin (collagen/fibrinogen domain containing) 1 | -5.45 | 0.480 | 1.00 | -1.46 | 12.39 |
   FGR | 208438_s_at | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | -3.03 | 0.480 | 1.00 | -1.13 | 5.75 |
   S100A12 | 205863_at | S100 calcium binding protein A12 (calgranulin C) | -8.86 | 0.480 | 1.00 | -2.63 | 15.19 |
Enzyme regulator | |||||||
   MMP14 | 202827_s_at | matrix metalloproteinase 14 (membrane-inserted) | 2.39 | 0.226 | 1.00 | -1.22 | -1.84 |
   TIMP3 | 201149_s_at | tissue inhibitor of metalloproteinase 3 | 2.22 | 0.467 | 1.00 | -1.71 | -3.43 |
   CASP1 | 211366_x_at | caspase 1, apoptosis-related cysteine protease | -2.73 | 0.165 | 1.00 | -1.30 | 1.01 |
   MME | 203434_s_at | membrane metallo-endopeptidase (CD10) | -3.23 | 0.476 | 1.00 | -2.35 | -1.29 |
   MMP8 | 207329_at | matrix metalloproteinase 8 (neutrophil collagenase) | -5.81 | 0.480 | 1.00 | -2.36 | 1.69 |
   RASGRP2 | 208206_s_at | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | -2.60 | 0.480 | 1.00 | 1.02 | 3.02 |
Unknown Function | |||||||
   CYFIP2 | 220999_s_at | cytoplasmic FMR1 interacting protein 2 | -2.68 | 0.031 | 1.00 | 1.14 | 1.09 |