Table 1 GO analysis results. Differentially expressed biological processes common in all cell lines after 48 h of exposure.
From: Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
GO term* | P-value/expression | Genes contributing to the differential expression | Total no. of genes in the GO term |
|---|---|---|---|
Negative regulation of helicase activity | < 0.01/down | TP53 | 2 |
Regulation of mitochondrial membrane permeability | < 0.01/down | TP53 | 8 |
Positive regulation of transcription, DNA-dependent | < 0.005/down | ARID1A, THRAP3, GLIS1, FOXD3, ARHGEF11, ATF6, ESRRG, NCOA1, FHL2, CTNNB1, SCAP, SMARCC1, ZBTB38, TP73L, PPARGC1A, NARG1, MAML3, IL31RA, CDK7, RNF14, PPARGC1B, NSD1, MAML1, SQSTM1, NOTCH4, HMGA1, TBN /// LOC441149, TBN, TRERF1, FOXO3A, ASF1A, PLAGL1, ARID1B, CREB5, SMARCD3, GATA4, GLIS3, RXRA, NCOA4, EHF, HTATIP, RBM14, RBM14 /// MGC15912, HBXAP, CRSP6, MAML2, ATF7IP, SURB7, SP1, SMARCC2, GRIP1, TBX5, RAN /// LOC391717, NARG1L, RB1, TXNDC, MED6, TP53BP1, ELL3, PIAS1, MKL2, TGFB1I1, CTCF, MAP2K3, PPARB, BRCA1, THRAP, PIAS2, SMAD2, ILF3, MECT1, CCNE1, MLL4, DYRK1B, NCOA3, NRIP1, RUNX1, SEC14L2, ATF4, PHF5A, G22P1, CRSP2, MED12 | 848 |
Negative regulation of JNK activity | < 0.01/down | HIPK3 | 5 |
Prenylated protein catabolism | < 0.01/down | PCYOX1 | 4 |
Negative regulation of survival gene product activity | < 0.01/down | BNIP3L, HRK, BCL2L1, BAX | 19 |
Ras protein signal transduction | < 0.01/down | PARK7, MFN2, CNKSR1, LCK, NOTCH2, IQGAP3, SOS1, LZTFL1, RASSF1, MRAS, PLD1, G3BP2, FGF2, IQGAP2, KIAA1961, RAPGEF6, G3BP, RREB1, RGL2, PLCE1, SHOC2, RASGRP2, IGF1, RASGRP1, TPM1, IQGAP1, LAT, GAS8, GRAP, KSR, NF1, GRB2, RASGRP4, RRAS, NU62, NUP62 /// IL4I1, CRKL, GRAP2 | 477 |
Cytoplasmic sequestering of NF-kappaB | < 0.005/down | FAF1, IL10, G3BP2, NFKBIA, BCL3 | 22 |
Regulation of MAPK activity | < 0.005/down | MAP3K6, SHC1, RGS4, LAX1, KIAA1804, TRIB2, SPRED2, DUSP2, MAP3K2, ZAK, PROK2, PIK3CB, ADRA2, EGF, FGF2, PRKAA1, PPP2, DUSP22, DAXX, MAPK3K5, DBNL, PP2CB, TRIB1, RGS3, PLCE1, DUSP8, HPK3, MAP3K11, PP2R1B, DUSP6, MBIP, MAP4K5, MAP3K9, SPRED1, HSPC121, GPS2, ADORA2B, GPS1, EDG5, PKN1, MAP4K1, MAP3K10, C5R1, PPP2R1, TRIB3, BIRC7, DUSP9 | 244 |
Sensory perception of smell | < 0.005/up | TAS1R1, TAS1R2, OR10K1, OR10, OR2C3, OR1C1, OR2W3, OR2L13, OR2M4, ADCY3, GRM7, SLIT2, YGT2A1, TAS2R1, OR2B2, ORB2B6, OR2W1, OR2B3, OR5U1, OR5V1, OR12D3, OR5V1 /// OR12D3, OR12D2, OR11A1, OR10C1, OR2H1, OR2H2, CYB5R4, TAS2R16, GRM8, TAS2R3, TAS2R4, TAS2R5, TAS2R38, OR6W1, TAS2R39, TAS2R40, TAS2R41, OR6B1, OR2S2, OR1J2, OR1J4, OR1Q1, OR51E1, OR51E2, OR52A1, OR51B4, OR51B2, OR51M1, OR51I1, OR51I2, OR52D1, OR6A2, OR10A4, OR5P2, OR5P3, PR5E1, OR10A3, OR5I1, OMP, OR8G1 /// LOC442754, OR8D1, OR8B2, OR8B8, TAS2R45, TAS2R7, TAS2R8, TAS2R9, TAS2R1, TAS2R13, TAS2R14, TAS2R50, OR4N4, OR1F1, OR1F2, OR2C1, OR1D2, OR1G1, OR1A2, OR1A1, OR3A2, OR3A1, OR1E1 /// OR1E2, OR4D1, OR4D2, OR7D2, OR7E19, OR7C1, OR7A5, OR7A10, OR7A17, OR7C2, OR1I1, OR10H2, C5R1 | 2589 |