From: Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
GO biological process | Cluster analysis | GO analysis | ||
---|---|---|---|---|
 | A549 cluster number (uncorrected p-value) | Beas-2B cluster number (uncorrected p-value) | MeT5A cluster number (uncorrected p-value) |  |
Antigen processing, endogenous antigen via MHC class I | 5 (9.52 × 10-10) | 12 (1.31 × 10-3) |  | A549 1 h up A549 24 h down |
Apoptotic program | 9 (2.58 × 10-3) | 6 (3.00 × 10-3) | 2 (2.55 × 10-4) | Beas-2B 24 h down A549 48 h down |
Cytoskeletal anchoring | 9 (2.04 × 10-3) | 6 (2.44 × 10-3), 16 (1.38 × 10-3) | 2 (2.85 × 10-3) | A549 24 h down MeT5A 48 h down |
Nucleosome assembly | 1 (5.68 × 10-4) | 3 (2.52 × 10-3), 5 (4.02 × 10-3), 13 (1.13 × 10-3) |  | Beas-2B 1 h down MeT5A 1 h up |
Regulation of DNA replication | 5 (9.56 × 10-3) | 11 (3.02 × 10-3) |  | A549 1 h up A549 6 h up Beas-2B 24 h down Beas-2B 48 h down |
Regulation of translational initiation | 1 (7.00 × 10-5) |  | 2 (5.73 × 10-3) | A549 48 h down Beas-2B 6 h down Beas-2B 48 h down MeT5A 1 h up |
Positive regulation of transcription, DNA-dependent | 8 (1.59 × 10-3) |  | 2 (3.73 × 10-3) | A549 48h down Beas-2B 6h down MeT5A 1h up MeT5A 48h down |
Positive regulation of I-kappaB kinase/NF-kappaB cascade | 1 (5.98 × 10-3), 4 (1.03 × 10-4) | 1 (2.36 × 10-3), 16 (1.17 × 10-4) | 2 (2.07 × 10-3) | A549 6h up A549 24h down A549 48h down Beas-2B 6h down Beas-2B 24h down Beas-2B 48h down MeT5A 1h up |
Negative regulation of survival gene product activity | 8 (9.92 × 10-3) |  | 2 (4.06 × 10-4) | A549 6h up A549 24h down A549 48h down Beas-2B 1h down Beas-2B 24h down Beas-2B 48h down MeT5A 1h up MeT5A 48h down |