Table 3 Asbestos-related genes. Previously identified potential asbestos-associated genes represented in significant clusters of all cell lines. (Affymetrix IDs are available upon request)

Mesothelioma-associated genes*

BIRC5

5

13

2

17q25

BTG2

5

7

3

1q32

CALU

9

8

3

7q32

CALU

9

8

3

7q32

COL1A1

5

10

2

17q21.33

COL4A1

5

8

2

13q34

COL5A1

5

14

2

9q34

COL6A2

5

3

2

21q22

FN1

9

6

3

2q34

HMGB1

9

3

2

13q12

HNRPH1

5

7

2

5q35

IGFBP4

4

10

3

17q21.2

KIBRA

5

6

3

5q34

LU

2

3

2

19q13

LU

2

10

3

19q13

NF2

5

7

2

22q12

PDLIM7

2

7

2

5q35

PDLIM7

5

7

2

5q35

PEG10

9

8

3

7q21

POM121

4

13

2

7q11

PTPRF

5

13

2

1p34

PXN

5

13

2

12q24

TPD52L1

5

6

1

6q22.31

TP53

5

7

2

17p13

TXN

11

1

1

9q31

VEGF

9

8

3

6p12

VEGF

9

8

3

6p12

VIL2

8

16

2

6q25.3

Human homologs of asbestos associated murine genes^†

BIRC4

6

7

1

Xq25

BIRC4

7

13

1

Xq25

BMP2

5

14

1

20p12

CD44

9

14

2

11p13

CSNK2A1

9

13

2

20p13

CTSB

1

14

1

8p22

FAS

1

8

1

10q24

FAS

1

8

1

10q24

IQGAP1

9

6

3

15q26

MAP4K4

1

8

3

2q11.2

PLEC1

9

6

2

8q24

PTPN14

9

6

3

1q32

PTPRF

5

13

2

1p34

RHOA

9

6

2

3p21

TP53

5

7

2

17p13

TRAM1

5

8

2

8q13

VAV2

5

13

2

9q34

Other asbestos-associated genes^‡

ADD3

5

8

3

10q24

CASP8

9

6

2

2q33.1

CDK10

5

13

2

16q24

COL12A1

9

8

2

6q13-14.1

FOSL2

2

3

3

2p23

IKBKB

9

16

2

8p11

KRAS

7

13

1

12p12

L1CAM

2

11

2

Xq28

MAPK1

3

5

3

22q11

MAPK1

9

6

2

22q11

MAPK1

9

6

2

22q11

NFKB2

5

13

3

10q24

PCDHGA6 ^§

12

10

3

5q31

PRKCD

5

6

3

3p21