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Figure 1 | BMC Genomics

Figure 1

From: The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse

Figure 1

MSCs modulate T cell functions. (a) T cell stimulation leads to several cycles of cell division (left panel) while the co-culture with MSCs (middle and right panel) almost completely abrogates T cell proliferation and induces cell division arrest. (b) Ki67, a nuclear antigen associated with cell proliferation is downregulated on stimulated T cells when co-cultured with MSCs. (c) MSCs inhibit AICD as depicted by a decrease of total annexin V positive T cells (UR+LR quadrants). (d) Intravenous injection of MSCs ameliorates EAE. MSCs injected at day 10 post immunization, after disease onset ameliorates EAE (*p < 0.05). Arrow indicates day of MSC injection. EAE (filled triangles), controls (filled squares).

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BMC Genomics

ISSN: 1471-2164

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