Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

Table 1 Summary of the clinicopathological data of the 177 and 89 STS samples

Factor	Diagnostic signature n = 177	Prognostic signature n = 89
Sex (male/female)	88/89	50/39
Age, median (range) years	66 (11 – 94)	69 (33 – 93)
Histological subtypes
Malignant fibrous histiocytoma (MFH)	61^¤	54
Leiomyosarcoma	40	27
Synovial sarcoma	32	0
Liposarcoma	16*	0
Malignant peripheral nerve sheath tumor	8	0
Myofibroblastic sarcoma	5	5
STS not otherwise specified	4	2
Extraskeletal osteosarcoma	3	1
Fibrosarcoma	3	0
Gastrointestinal stromal tumors	3	0
Epithelioid sarcoma	1	0
Malignant mesenchymoma	1	0
Grade
II	6	1
III	32	12
IV	139	76
Tumor size
Median (range) cm	8 (1–40)	9 (2–30)
< 5 cm	41	19
5 – 10 cm	74	38
>10 cm	62	32
Tumor location
Extremity	144	78
Trunk wall	19	7
Retroperitoneum	7	3
Other	7^#	1
Tumor depth
Superficial	37	22
Deep	118	63
Unclassified	22	4
Necrosis
Absent	48	23
Present	106	66
Unclassified	23	0
Vascular invasion
Absent	121	72
Present	31	17
Unclassified	25	0
Treatment
Surgery alone	107	58
Postoperative radiotherapy	51	22
Postoperative chemotherapy	3	2
Postoperative radio- and chemotherapy	10	7
Preoperative radio- or chemotherapy	6	0
Surgery
Wide	90	57
Marginal	66	28
Intralesional	15	4
Unclassified	6	0

^¤Includes 47 storiform, 13 myxoid, and 1 giant-cell MFH
* Includes 4 myxoid/round cell liposarcomas, 6 dedifferentiated liposarcomas, and 6 pleomorphic liposarcomas
^# Includes localizations in the abdomen, the mediastinum, and the head and neck

ISSN: 1471-2164