Figure 1From: Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphineCorrelation of brain Comt and Gnb1 expression with morphine efficacy. Comt and Gnb1 expression in BXD RI strains were correlated with the slope of the morphine dose-response curve (a, n = 23) (derived from [51]), with the analgesia observed with 16 mg/kg of morphine (b, n = 22) (analgesia is expressed as percent of maximum effect and is derived from Fig. 1 of [52]), or with morphine consumption in a two-bottle choice study (c, n = 22) [53] in the BXD RI strains. All expression and behavioural data can be found on the WebQTL database [13]. Comt expression was assessed using the single associated probe set (98535_at), while Gnb1 expression was assessed using probe set 94854_g_at. Rank order correlations were: Top, -0.535, P = 0.0076; middle, -0.470, P = 0.026; and, bottom, -0.586, P = 0.0035.Back to article page