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Figure 1 | BMC Genomics

Figure 1

From: Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine

Figure 1

Correlation of brain Comt and Gnb1 expression with morphine efficacy. Comt and Gnb1 expression in BXD RI strains were correlated with the slope of the morphine dose-response curve (a, n = 23) (derived from [51]), with the analgesia observed with 16 mg/kg of morphine (b, n = 22) (analgesia is expressed as percent of maximum effect and is derived from Fig. 1 of [52]), or with morphine consumption in a two-bottle choice study (c, n = 22) [53] in the BXD RI strains. All expression and behavioural data can be found on the WebQTL database [13]. Comt expression was assessed using the single associated probe set (98535_at), while Gnb1 expression was assessed using probe set 94854_g_at. Rank order correlations were: Top, -0.535, P = 0.0076; middle, -0.470, P = 0.026; and, bottom, -0.586, P = 0.0035.

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