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Table 4 Drug binding residues

From: The actin multigene family of Paramecium tetraurelia

 

phalloidin

latrunculin Ab

 

G158

R177

D179

D157

R183/D184

R210/D211

K21/E214/K215

actin1-1

G

R

D

S

R

A

R

D

K

E

K

actin1-4

G

R

D

S

R

A

R

D

K

E

K

actin1-5

G

R

D

S

R

A

R

D

K

E

K

actin1-6

G

K

N

S

R

L

K

N

K

E

R

actin1-7

G

R

D

S

R

A

K

D

K

E

K

actin1-8

G

R

Y

S

S

T

R

D

K

E

K

actin1-9

G

R

C

C

N

A

D

I

K

E

K

actin2-1

G

K

H

S

R

D

N

A

D

T

K

actin3-1

G

R

D

S

Y

A

S

L

Y

V

A

actin4-1

G

Q

P

I

E

I

P

D

K

F

I

actin5-1(ARP1)

G

R

D

V

R

D

I

I

K

Y

K

actin6-1

G

F

S

L

A

E

D

K

S

E

E

actin7-1(ARP2/4)

G

R

D

C

E

Y

S

L

M

Y

G

actin8

G

F

N

S

K

S

L

Q

Q

Q

Q

actin9(ARP10)

G

G

Y

L

R

E

C

Y

D

T

Y

ARP2-1

G

R

N

A

R

H

R

E

K

E

A

ARP3-1

G

H

P

S

R

D

R

E

K

E

K

ALP1-1(ARP5)

G

R

N

L

L

N

L

Q

Q

E

R

  1. a Analysis was performed using Clustal W.
  2. b each combination represents an allele in yeast mutagenesis studies.
  3. Bold and italic, all interacting residues are present; italic, not all residue are present.
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BMC Genomics

ISSN: 1471-2164

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