Figure 4

Phylogenetic distribution of proteins associated with probe sets. Percentage of proteins with homologues in a given organism: Homo sapiens (human), Brachydanio rerio (fish), Xenopus laevis (frog), Drosophila melanogaster (fly), Caenorhabditis elegans (worm), and Saccharomyces cerevisiae (yeast). For each organism, the leftmost column indicates homologues found for proteins from the 1,675 probe sets with largest gene expression changes, the middle column those from the complete set of 16,752 probe sets, and the rightmost column those from the 1,675 probe sets with smallest gene expression changes. In each column, the dark bottom part indicates the percentage of proteins aligned along their full length (less than 30 amino acids unmatched at the N- and C-termini of both sequences), and the lighter upper part is the percentage of proteins with sequence similarity (no length restriction). Proteins were considered similar with a BLAST E-value < 1e-6.