Figure 3

Identification of functional regulatory sequences in the proximal promoter region of the HL gene by rVista. Of the proximal promoter regions of the rat and human HL genes, 600 bp were submitted to the rVista sequence analysis software, and searched for conserved clusters of TFBS for a selection of 50 transcription factors known to be expressed in mammalian liver. A vertical line indicates the position of the conserved TFBS relative to the human sequence (x-axis, numbering is relative to the transcriptional start site). Homology between the rat and human sequence is given as described for figure 1. Three clusters of conserved TFBS are identified, and designated A (-240/-200), B (-80/-40) and C (-25/+5). In human-mouse comparison, these clusters are also evident with an additional cluster at -295/-265.