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Figure 2 | BMC Genomics

Figure 2

From: Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination

Figure 2

Organization of tandem repeat arrays located within the control region of halibut mtDNAs. (A) Schematic organization of the control region (CR) representing all analysed halibut species and specimens. CR is located between the tRNA genes Pro (P) and Phe (F), and contains the highly conserved termination association sequence (TAS: TACATGTATAA), conserved sequence box D (CSB-D: CCTGGCATTTGGTTCC), pyrimidine sequence run (Py-run: TTCTCTTTTTTTTTTTCCTTTC), and the two conserved sequence boxes associated with oriH (CSB-2: AAACCCCCCTACCCCCC, and CSB-2: TGAAAACCCCCCGGAAACA). The heteroplasmic tandem repeat (HTR) array is located between CSB-3 and tRNA-F gene. (B) Detailed view of the HTR array in cloned and sequenced CR from the Atlantic halibut (H. hippoglossus) specimens. The 61-bp HTR motif was found in 12, 13, 19, and 15 copies in Hh-1, Hh-2, Hh-3, and Hh-4, respectively. The HTR motif starts with an 11-bp submotif (boxed), also found freestanding flanking the 61-bp array motif. Eight different variants of the HTR motif (I-VIII) were noted in Atlantic halibut. Hh-2 has one additional freestanding 11-bp motifs compared to the other specimens. (C) HTR array in Pacific halibut (H. stenolepsis) specimens Hs-1 to Hs-4. Two different variants of the motif were found. (D) HTR array in Greenland halibut (R. hippoglossoides) specimens Rh-1 to Rh-4. Five different variants of the motif were found.

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