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Table 1 Cell cycle regulated transcription factors in yeast

From: Systematic identification of cell cycle regulated transcription factors from microarray time series data

TFa

Phaseb

p-value

q-value

Average AC score

kc

Tsaid

Function

    

M/G1

G1

S

G2

M

   

ABF1

 

2.0E-05

5.5E-04

-3.5

-7.0

1.6

9.2

5.5

7

no

ARS-Binding Factor 1

ASH1

 

6.0E-04

0.0055

-4.0

10.4

5.7

6.2

-9.1

3

no

inhibitor of HO transcription

BAS1

 

0.0011

0.0074

-0.3

-4.0

-2.3

1.6

5.3

7

yes

purine and histidine biosynthesis

DAL80

 

1.3E-04

0.0019

4.1

-4.1

-4.6

-5.4

2.1

0

no

nitrogen degradation

FKH2

M

7.8E-04

0.0064

-9.1

-11.4

-4.6

16.4

18.1

7

yes

activation of M phase specific target genes

FZF1

 

9.9E-04

0.0072

0.0

-7.6

-1.9

0.0

6.3

7

no

sulfite metabolism

GAT3

 

9.9E-04

0.0072

-2.2

14.1

1.5

-6.9

-7.7

3

yes

unknown

GCR2

 

5.0E-05

9.0E-04

-2.9

-8.1

5.0

5.1

6.9

6

no

glycolysis regulatory protein

HAP2

 

1.6E-04

0.0020

-2.5

-6.0

2.8

3.4

5.0

6

no

global regulator of respiratory gene expression

HAP3

 

0.0077

0.035

2.1

-7.6

-2.6

-1.1

5.7

8

no

global regulator of respiratory gene expression

HIR1

S

8.0E-04

0.0064

-10.7

-1.2

13.5

7.0

4.8

5

yes

histone Regulation

HIR2

S

2.3E-04

0.0027

-12.5

-0.3

16.5

9.6

4.3

5

yes

histone Regulation

HIR3

S

5.0E-05

9.0E-04

-9.9

-1.4

13.8

7.7

2.7

5

no

histone Regulation

IFH1

 

0.0075

0.035

0.8

-9.3

-4.7

-7.4

9.0

8

no

regulate silencing at telomeres and HM loci

KSS1

 

8.1E-04

0.0064

0.6

-6.1

-6.2

-2.0

6.2

8

no

filamentous growth and pheromone response

MBP1

G1, S

0

2.0E-04

-10.6

22.2

11.7

-1.8

-17.4

3

yes

cell cycle regulation from G1 to S phase

MCM1

G2, M

0.0021

0.011

1.5

-7.9

-7.8

7.9

15.6

8

yes

activator of G2 and M phase-specific

MET32

 

3.0E-05

6.4E-04

-0.6

-6.2

-0.3

5.2

5.0

7

no

methionine biosynthetic

MET4

 

0.0019

0.011

-8.0

-2.3

11.4

12.7

-3.1

5

yes

regulator of the sulfur amino acid pathway

MSN1

 

6.2E-04

0.0055

-4.4

1.7

5.5

3.7

0.2

5

no

invasive growth;; hyperosmotic response

NDD1

M

5.3E-04

0.0052

-1.8

-13.3

-7.9

15.8

23.2

7

yes

activator of a set of late-S-phase-specific genes

NRG1

 

0.0035

0.018

2.4

-3.8

-3.8

-5.5

4.8

8

no

glucose repression; regulates a variety of

OTU1

M/G1

0.0019

0.011

0.8

-9.7

-4.2

-0.7

9.8

7

no

may contribute to regulation of protein

PHO2

 

1.1E-04

0.0019

-3.1

-3.1

2.0

3.8

4.0

6

no

phosphate metabolism

REB1

 

0

8.0E-05

-2.0

-7.4

1.5

6.5

7.7

7

no

RNA polymerase I enhancer binding protein

RGM1

 

0.0063

0.031

-0.7

10.3

0.0

-6.0

-8.4

2

no

putative transcriptional repressor

RME1

 

3.0E-05

6.4E-04

-5.0

-2.7

5.9

5.3

0.6

5

no

promotes mitosis ; sporulation

SPT2

 

0.0022

0.012

-5.2

-5.2

5.1

6.7

4.5

6

no

interact with histones and SWI-SNF components

SRD1

M/G1

0.0084

0.035

1.0

-10.3

-0.3

0.1

7.7

7

no

rRNA processing

STP4

G2/M

1.4E-04

0.0019

3.2

6.0

-3.7

-5.4

-0.6

1

no

has similarity to Stp1p, Stp2p, and Stp3p

SWI4

G1, S

0

5.0E-05

-16.4

19.6

16.2

11.0

-17.6

4

yes

regulate gene expression of G1 specific

SWI5

G1

0.0054

0.028

9.5

13.0

-6.7

-11.9

-9.3

2

yes

activates expression of early G1-specific genes

SWI6

G1, S

0

5.0E-05

-16.8

19.8

15.8

11.0

-16.8

4

yes

regulate transcription at the G1/S transition

TBS1

 

4.8E-04

0.0049

-3.7

-3.0

6.8

6.3

2.0

6

no

unknown

TYE7

G1/S

0.0098

0.039

0.1

-7.5

-2.3

1.0

5.6

7

no

putative activator in Ty1-mediated gene

UGA3

 

0.0013

0.0086

3.1

-1.5

-4.8

-6.2

2.1

0

no

GABA-dependent induction of GABA genes

UPC2

 

0.0015

0.0092

0.9

-9.0

-3.2

-0.7

8.5

7

no

sterol regulatory element binding protein

YAP7

 

0.0017

0.010

0.0

-7.7

-2.8

0.0

7.4

7

no

putative basic leucine zipper transcription

YER184C

 

0.0093

0.038

4.7

1.9

-7.6

-6.8

2.3

0

no

putative zinc cluster protein

YGR067C

 

0.0063

0.031

2.7

-5.7

-4.3

-4.1

6.4

8

no

unknown

YOX1

M/G1

2.5E-04

0.0027

3.5

-3.8

-7.5

-6.9

7.2

0

yes

repress ECB (early cell cycle box) activity

YPR196W

 

1.3E-04

0.0019

2.9

4.0

-4.3

-7.7

-0.3

1

no

putative maltose activator

  1. a: known CCRTFs are shown in bold; b: known phases of TFs; c: inferred phases for TFs by Formula (6); d: whether identified as CCRTFs in [13]