Table 1 Properties of retained and constitutive introns. For all intron parameters the medians are reported. The last two columns report the statistical significance of the differences of the distributions by the Kolmogorov-Smirnov test (KS) and Student's t-test (ST); n/s – non significant.
From: Computational analysis of splicing errors and mutations in human transcripts
| Â | introns | Â | Â | |
|---|---|---|---|---|
| Â | Retained | Constitutively spliced | KS | ST |
Set size | 1197 | 137580 | Â | Â |
Intron length (nucleotides) | 337 | 1481 | <10-15 | <10-15 |
Splice site scores | ||||
Acceptor site of the of 5'-exon | 18,60 | 19,09 | <10-15 | <10-11 |
Donor site | 18,17 | 18,80 | <10-15 | <10-15 |
Acceptor | 18,03 | 19,06 | <10-15 | <10-15 |
Donor site of 3'-exon | 18,74 | 18,79 | n/s | n/s |
Cis-acting elements (candidate sites per nucleotie) | ||||
ESEfinder: SC35 | 0,046 | 0,034 | <10-15 | <10-15 |
ESEfinder: SF2/ASF | 0,040 | 0,028 | <10-15 | <10-15 |
ESEfinder: SRp40 | 0,041 | 0,038 | <10-15 | Â |
ESEfinder: SRp55 | 0,022 | 0,022 | <10-15 | n/s |
RESCUE-ESE | 0,050 | 0,068 | <10-15 | <10-15 |
PESE | 0,043 | 0,035 | <10-15 | <10-15 |
PESS | 0,013 | 0,048 | <10-15 | <10-15 |
Relative position | ||||
by ordinal number | 0,6 | 0,5 | <10-15* | <10-15 |
by gene | 0,671 | 0,597 | <10-9 | <10-15 |
by mRNA | 0,446 | 0,354 | <10-15 | <10-15 |
by mRNA w/o last exon | 0,688 | 0,575 | <10-15 | <10-15 |