Table 1 Comparison of the conserved G1, G2, G3, and G4 motifs of the mGBPs. The canonical GTP motifs of all mGBPs and the overall consensus sequence are shown. Amino acid substitutions are highlighted in bold.
From: Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies
| Â | G1 | G2 | G3 | G4 |
|---|---|---|---|---|
mGBP1 | GF YH TGKS | T | DTEG | TL RD |
mGBP2 | GLYRTGKS | T | DTEG | TL RD |
mGBP3 | GLYRTGKS | T | DTEG | A VRD |
mGBP4 | GWSH TGKS | - | ---- | ---- |
mGBP4.1 | GWSH TGKS | - | DTEG | TVRD |
mGBP5 | GLYRTGKS | T | DTEG | TL RD |
mGBP5.a | GLYRTGKS | - | ---- | TL RD |
mGBP6 | GLYRTGKS | T | DTEG | TVRD |
mGBP7 | GLYRTGKS | T | DTEG | TVRD |
mGBP8 | GLYRTGKS | T | DTEG | TVRD |
mGBP9 | GLYRTGKS | T | DTEG | TVRD |
mGBP10 | GWS RTGKS | T | DTEG | I VRD |
mGBP11 | GLYRTGKS | T | DTEG | TVRD |
consensus | GxxxTGKS | T | DTEG | x(V/L)RD |