Strand bias structure in mouse DNA gives a glimpse of how chromatin structure affects gene expression

BMC Genomics

Table 1 Basics statistics

	Actual genome	Hybrid genome	Shuffled genome
A) Number of segments
segments defined by algorithm	23482	8229	2013
B) Median absolute AT-bias
segments defined by algorithm	3.68%	1.96%	0.54%
segments of random position	1.86%	0.82%	0.43%
C) Median absolute AT-skew
segments defined by algorithm	6.26%	3.46%	0.93%
segments of random position	3.21%	1.41%	0.73%

In this table, AT-bias = median absolute (A-T)/(A+C+G+T). In this table, AT-skew = median absolute (A-T)/(A + T). Absolute values are used in this table to give meaning to the results for the random sample. The comparison between the actual and shuffled genomes confirms that the algorithm is finding real features in the real genome. The comparison between the actual and hybrid genome confirms that the average segment in the real genome is of stronger bias than a segment generated by transcription.

ISSN: 1471-2164