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Table 4 Top 30 reporter metabolites.

From: Analysis of Aspergillus nidulans metabolism at the genome-scale

Reporter metabolites

Effect of growth medium

Effect of genotype

N-Acetyl-L-glutamate (mitochondrial)

4-Phospho-L-aspartate

Methanol

L-Xylulose

Ethanol

D-Sorbitol

Ethanol (mitochondrial)

N-Acetyl-D-glucosamine 1-phosphate

Acetaldehyde (mitochondrial)

Oxaloglutarate (mitochondrial)

Acetaldehyde

Acetate (mitochondrial)

Carnitine

Glutathione

O-Acetylcarnitine

NH3 (extracellular)

N-Acetyl-L-glutamate 5-phosphate (mitochondrial)

3-(4-Hydroxyphenyl)pyruvate

D-Lactate

L-Tyrosine

Acetyl-CoA (mitochondrial)

D-Xylulose

Formaldehyde

N-(L-Arginino)succinate

3-(4-Hydroxyphenyl)pyruvate

O-Phospho-L-homoserine

L-Tyrosine

D-Mannitol

L-Xylulose

L-Glutamate

D-Sorbitol

N-Acetyl-L-glutamate 5-phosphate (mitochondrial)

CoA (mitochondrial)

Acetate

N-(L-Arginino)succinate

Starch (extracellular)

Acetate (mitochondrial)

Glycogen (extracellular)

2-Hydroxybutane-1,2,4-tricarboxylate (mitochondrial)

N-Acetyl-L-glutamate 5-semialdehyde (mitochondrial)

N-Acetyl-L-glutamate 5-semialdehyde (mitochondrial)

Glycerol 3-phosphate

Tartrate

NH3

Oxaloglycolate

gamma-Amino-gamma-cyanobutanoate

NAD+ (mitochondrial)

Sterigmatocystin

NADH (mitochondrial)

Dihydrosterigmatocystin

4-Aminobutyraldehyde (mitochondrial)

Versiconal hemiacetal acetate

4-Aminobutanoate (mitochondrial)

Water (mitochondrial)

(S)-Lactaldehyde (mitochondrial)

Xylitol

L-Kynurenine

D-Arabitol

L-Ornithine (mitochondrial)

N6-(1,2-Dicarboxyethyl)-AMP

  1. Reporter metabolites identified based on the reconstructed metabolic network and expression data [28]. Two lists are shown, which correspond to highly regulated metabolites (ranked according to p-values) upon a change in the growth medium and in the genotype. Common metabolites to both lists are shown in italic.