Table 1 [8]-Gene name and function of the eight members of the DAL5 subfamily in S. cerevisiae.
Gene name | Function | References |
|---|---|---|
YJR152w (DAL5) | Encodes an allantoate and ureidosuccinate permease, expression is constitutive but sensitive to nitrogen catabolite repression. Subtelomeric in S. cerevisiae | [20, 21]. |
YCR028c (FEN2) | A membrane pantothenate transporter, regulated by high concentrations of pantothenate. Pantothenate is essential for the biosynthesis of coenzyme A, which is a carrier of activated C2 units in sterol biosynthesis. FEN2 was first identified in a screen for mutants resistant to fenproprimorph, an inhibitor of ergosterol biosynthesis | [22, 23] |
YGR065c (VHT1) | Encodes a high affinity H+-biotin (vitamin H) permease different from mammals, regulated by high concentrations of biotin. The biotin uptake and biosynthesis is reciprocally regulated by iron, with uptake being activated when iron is scarce | [22, 24]. |
YGR260w (TNA1) | Encodes a high affinity nicotinic acid (vitamin B3) permease. The mRNA levels increase strongly at reduced extracellular concentrations of both nicotinic acid and para-aminobenzoate (PABA) but are not inhibited by high concentrations of the same substrates. Subtelomeric in S. cerevisiae | [25, 26]. |
YLR004c (TH173) | Encodes a membrane protein in the endoplasmic reticulum that is strongly regulated by thiamine. It is unable to transport thiamine but might be involved in transport of thiamine precursors. The metabolite is probably a compound that can be used by yeast to generate the thiazole precursor HET. The expression level is upregulated by Pdc2 (pyruvate decarboxylase) and Thi2 (thiamine) | [10, 26-30]. |
YAL067c (SEO1) | Might be involved in the transport of some sulphur compound (which remains to be identified) since the overexpression of the SEO1 gene allowed growth on low concentration of methionine sulphoxide and supressed the ethionine sulphoxide resistance. The gene does not encode a methionine permease Subtelomeric in S. cerevisiae | [31]. |
YLL055w (YCT1) | Might be involved in the intracellular transport of allantoate since its transcripts are overexpressed during nitrogen starvation (similar to DAL5) The protein is localized in the endoplasmic reticulum. Subtelomeric in S. cerevisiae | [32]. |
YIL166c | Putative protein with elevated mRNA expression by sulfur limitation. YIL166c is a non-essential gene. Subtelomeric in S. cerevisiae | [10, 27-29]. |