Figure 1

Genomic organization of the H2-Q , - T and - M region. (A) Gene content of the H2-Q, -T and -M regions on chromosome 17 of mouse C57BL/6 strain. The Mhc class Ib genes with coding potential are represented by yellow boxes. The genes determined by our initial analysis using GENSCAN program are indicated with a GS number. Gene contents regarding H2-M1 and -M10 families were omitted in this figure. The regions indicated by the squiggles are the regions where the non-Mhc genes are interspersed. The scale bar indicating 20 kb applies to the H2-Q and -T regions. (B) Dot-plot comparisons of the mouse H2-Q (left) and -T (right) regions. Comparison of the sequence to itself reveals the duplicated regions. (C) Phylogenetic tree analysis of H2-Q (left) and -T (right) genes based on nucleotide sequences of the entire coding region. Gene pairs showing highly similar sequences (>85%) in H2-T region are represented by red circles. Bootstrap values (1000 replicates) are indicated. A scale bar of "0.1" represents a branch-length of 0.1 nucleotide substitutions per site.