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Table 1 Typical endothelial signatures of the cells isolated from human cancer and normal tissue specimens

From: Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium

 

CD31/PECAM-1

vWF*

VE-cadherin

alpha-SMA

HOC-EC (n = 9)

73–98

75–99

97–100

0

HKC-EC (n = 3)

85–93

27–67

nt

0

HA-EC (n = 9)

94–99

30–90

99–100

0

HSk-EC (n = 2)

95–97

80–99

nt

0

HUVEC (n = 6)

80–99

90–99

99–100

0

  1. Percentages of positive cells analyzed by immunohistochemistry evaluating a total of 500 cells/population. In parentheses are the number of independent human EC populations evaluated (HOC-EC = ovarian carcinoma EC; HKC-EC = kidney carcinoma EC; HA-EC = adrenal gland-EC; HSk-EC = skin-EC, HUVEC = umbilical vein EC).
  2. Shown are the range of values obtained for the different endothelial cell types.
  3. * Population showing positivity values below 65% were not utilized. nt=not determined