Table 3 Transcriptional differences: tumor vs normal tissue derived EC

Structural

A

Hs.370287

ADAM23

A disintegrin and metalloproteinase domain 23

Hs.118127

ACTC

Actin, alpha, cardiac muscle

Hs.533336

BAMBI

BMP and activin membrane-bound inhibitor homolog

Hs.489142

COL1A2

Collagen, type I, alpha 2

Hs.443625

COL3A1

Collagen, type III, alpha 1

Hs.210283

COL5A1

Collagen, type V, alpha 1

Hs.211933

COL13A1

Collagen, type XIII, alpha 1

Hs.409034

COL15A1

Collagen, type XV, alpha 1

Hs.80552

DPT

Dermatopontin

Hs.412597

DSG2

Desmoglein 2

Hs.159291

DRP2

Dystrophin related protein 2

Hs.371903

GYPE

Glycophorin E

Hs.190495

GPNMB

Glycoprotein (transmembrane) nmb

Hs.328232

GPC1

Glypican 1

Hs.435557

KIF5C

Kinesin family member 5C

Hs.436367

LAMA3

Laminin, alpha 3

Hs.519972

HLA-F

Major histocompatibility complex, class I, F

Hs.490874

MTX1

Metaxin 1

Hs.464469

MYOM1

Myomesin 1 (skelemin)

Hs.504687

MYL9

Myosin, light polypeptide 9, regulatory

Hs.464829

CDH2

N-cadherin

Hs.116471

CDH11

OB-cadherin

Hs.487925

PDE4DIP

Phosphodiesterase 4D interacting protein (myomegalin)

Hs.157818

KCNAB1

Potassium voltage-gated channel, shaker-related subfamily, beta member 1

Hs.407643

PCDH9

Protocadherin 9

Hs.106511

PCDH17

Hypothetical protein LOC144997

Hs.7972

RIPX

Rap2 interacting protein x

Hs.73800

SELP

Selectin P

Hs.468675

T1A-2

T1A-2 (lung type-I cell membrane-associated glycoprotein)

Hs.143250

TNC

Tenascin C

Hs.371147

THBS2

Thrombospondin 2

Hs.443681

CSPG2

Versican

Hs.529901

XIST

X (inactive)-specific transcript

Enzymatic

B

Hs.459538

ALDH1A3

Aldehyde dehydrogenase 1 family, member A3

Hs.421202

ABCA2

ATP-binding cassette, sub-family A (ABC1), member 2

Hs.489033

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Hs.646

CPA3

Carboxypeptidase A3

Hs.75360

CPE

Carboxypeptidase E

Hs.252549

CTSZ

Cathepsin Z

Hs.154654

CYP1B1

Cytochrome P450, family 1, subfamily B, polypeptide 1

Hs.516493

FAP

Fibroblast activation protein, alpha

Hs.30332

GFPT2

Glutamine-fructose-6-phosphate transaminase 2

Hs.301961

GSTM1

Glutathione S-transferase M1

Hs.470126

KYNU

Kynureninase (L-kynurenine hydrolase)

Hs.65436

LOXL1

Lysyl oxidase-like 1

Hs.307734

MME

Membrane metallo-endopeptidase

Hs.478289

NLGN1

Neuroligin 1

Hs.30954

PMVK

Phosphomevalonate kinase

Hs.77274

PLAU

Plasminogen activator, urokinase

Hs.446429

PTGDS

Prostaglandin D2 synthase 21 kDa

Hs.501280

PRSS11

Protease, serine, 11 (IGF binding)

Hs.303090

PPP1R3C

Protein phosphatase 1, regulatory (inhibitor) subunit 3C

Hs.128013

PRSS3

Protease, serine, 3

Hs.270279

TYRP1

Tyrosinase-related protein 1

Hs.13225

B4GALT4

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4

Hs.69009

B3GNT3

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3

Signaling

C

Hs.143102

AB012943

Amine oxidase, copper containing 2

Hs.167046

ADORA2B

Adenosine A2b receptor

Hs.483909

ADMR

Adrenomedullin receptor

Hs.132902

CAP2

CAP, adenylate cyclase-associated protein, 2 (yeast)

Hs.502328

CD44

CD44 antigen

Hs.78065

C7

Complement component 7

Hs.473133

DOK5

Docking protein 5

Hs.523173

ENTPD1

Ectonucleoside triphosphate diphosphohydrolase 1

Hs.511899

EDN1

Endothelin 1

Hs.1407

EDN2

Endothelin 2

Hs.183713

EDNRA

Endothelin receptor type A

Hs.481371

FAT

FAT tumor suppressor homolog 1 (Drosophila)

Hs.352

FOLR3

Folate receptor 3 (gamma)

Hs.432395

GPR39

G protein-coupled receptor 39

Hs.79022

GEM

GTP binding protein overexpressed in skeletal muscle

Hs.198612

GPR51

G protein-coupled receptor 51

Hs.156855

GABRG3

Gamma-aminobutyric acid (GABA) A receptor, gamma 3

Hs.167017

GABBR1

Gamma-aminobutyric acid (GABA) B receptor, 1

Hs.98262

GRIK2

Glutamate receptor, ionotropic, kainate 2

Hs.124161

HCN2

Hyperpolarization activated cyclic nucleotide-gated potassium channel 2

Hs.370984

IGSF4C

Immunoglobulin superfamily, member 4C

Hs.438102

IGFBP2

Insulin-like growth factor binding protein 2

Hs.369982

IGFBP5

Insulin-like growth factor binding protein 5

Hs.81134

IL1RN

Interleukin 1 receptor antagonist

Hs.126256

IL1B

Interleukin 1, beta

Hs.129751

IL17R

Interleukin 17 receptor

Hs.514535

LGALS3BP

Lectin, galactoside-binding, soluble, 3 binding protein

Hs.125474

LPXN

Leupaxin

Hs.36566

LIMK1

LIM domain kinase 1

Hs.304475

LCP2

Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa)

Hs.418367

NMU

Neuromedin U

Hs.514556

NPTX1

Neuronal pentraxin I

Hs.8546

NOTCH3

Notch homolog 3 (Drosophila)

Hs.434255

PSD3

Pleckstrin and Sec7 domain containing 3

Hs.506076

PTPRR

Protein tyrosine phosphatase, receptor type, R

Hs.436456

ROR1

Receptor tyrosine kinase-like orphan receptor 1

Hs.24950

RGS5

Regulator of G-protein signalling 5

Hs.194691

RAI3

Retinoic acid induced 3

Hs.95655

SECTM1

Secreted and transmembrane 1

Hs.516726

SCG2

Secretogranin II (chromogranin C)

Hs.156540

SGNE1

Secretory granule, neuroendocrine protein 1 (7B2 protein)

Hs.75149

SH3GL2

SH3-domain GRB2-like 2

Hs.444915

SLC1A1

Solute carrier family 1, member 1

Hs.448520

SLC7A2

Solute carrier family 7, member 2

Hs.351306

SLC16A4

Solute carrier family 16, member 4

Hs.192686

SLC20A2

Solute carrier family 20, member 2

Hs.12409

SST

Somatostatin

Hs.62886

SPARCL1

SPARC-like 1 (mast9, hevin)

Hs.233160

STC2

Stanniocalcin 2

Hs.258326

LOC51760

Synaptotagmin 1

Hs.349470

SNCG

Synuclein, gamma

Hs.62192

TF

Tissue factor

Hs.534363

UCN

Urocortin

Hs.73793

VEGF

Vascular endothelial growth factor

Hs.306251

ERBB3

V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Transcriptional factors and regulators

D

Hs.65734

ARNTL

Aryl hydrocarbon receptor nuclear translocator-like

Hs.397705

CAMTA1

Calmodulin binding transcription activator 1

Hs.157002

DZIP1

DAZ interacting protein 1

Hs.22634

ETV1

ets variant gene 1

Hs.155591

FOXF1

Forkhead box F1

Hs.519385

FOXD1

Forkhead related activator 4 (FREAC-4)

Hs.121443

HOP

Homeodomain-only protein

Hs.180919

ID2

Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

Hs.371013

JMJD2B

Jumonji domain containing 2B

Hs.434284

LRRC17

Leucine rich repeat containing 17

Hs.527007

MEOX2

Mesenchyme homeo box 2 (growth arrest-specific homeo box)

Hs.89404

MSX2

Msh homeo box homolog 2 (Drosophila)

Hs.1497

RARG

Retinoic acid receptor, gamma

Hs.149261

RUNX1

Runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)

Hs.465087

SMAD7

SMAD, mothers against DPP homolog 7 (Drosophila)

Hs.360174

SNAI2

Snail homolog 2 (Drosophila)

Hs.89583

TLX1

T-cell leukemia, homeobox 1

Hs.149991

THOC2

THO complex 2

Hs.125962

TFEC

Transcription factor EC

Hs.1145

WT1

Wilms tumor 1

Hs.490510

ZNF212

Zinc finger protein 212

Hs.22653

ZNF365

Zinc finger protein 365

Hs.147765

ZNF415

Zinc finger protein 415

DNA replication, Cell Cycle and Apoptosis

E

Hs.75823

AF1Q

ALL1-fused gene from chromosome 1q

Hs.150749

BCL2

B-cell CLL/lymphoma 2

Hs.122908

CDT1

DNA replication factor

Hs.9999

EMP3

Epithelial membrane protein 3

Hs.52903

8FSTL3

Follistatin-like 3 (secreted glycoprotein)

Hs.130853

HIST1H2BD

Histone 1, H2bd

Hs.534369

HIST1H2BE

Histone 1, H2be

Hs.152944

LOH11CR2A

Loss of heterozygosity, 11, chromosomal region 2, gene A

Hs.432132

G0S2

Putative lymphocyte G0/G1 switch gene

Hs.514913

SERPINB2

Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2

Others and unknown

F

Hs.441783

C14orf78

C14orf78

Hs.516956

C20orf91

chromosome 20 open reading frame 91 Hs.17936

DKFZP434H132

DKFZP434H132 protein

Hs.132994

DKFZP434C171

DKFZP434C171 protein

Hs.41707

HSPB3

Heat shock 27 kDa protein 3

Hs.432616

IMP-3

IGF-II mRNA-binding protein 3

Hs.534372

INE1

Inactivation escape 1

Hs.464563

KIAA0802

KIAA0802

Hs.65750

KIAA1086

KIAA1086

Hs.472010

PRNP

Prion protein (p27-30)

AC006276

U62317

W26626

W28546