Figure 3

Example of strain variation in gene number and/or order within An. gambiae. Orthologous genomic regions from the Sua and PEST strains that contain different numbers of CPR genes are depicted. The Sua clone sequenced by Dotson et al. [14] contains three CPR genes, two of which, Agcp2b and Agcp2c, are orthologs of the genes CPR97 and CPR100 that we identified in the PEST strain. Due to a duplication event, the other Sua gene, Agcp2a, is orthologous to both the first half of the pseudogene PseudoA and the second half of CPR96. The intergenic regions between the three Sua genes are also present in the PEST genome sequence, but there is also an additional 24.3 kb segment containing six additional CPR genes. It is not known whether this segment is absent in the Sua strain or has simply been rearranged relative to PEST. Diagram is not drawn to scale; single-copy genes (those not in sequence clusters) are underlined.