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Table 4 Enriched GO terms for switch-like genes. Terms are organized by cellular component (CC), biological process (BP), and molecular function (MF). Enrichment scores are the number of observed genes over the number of expected genes. P-values were computed using the hypergeometric distribution.

From: Switch-like genes populate cell communication pathways and are enriched for extracellular proteins

 

GO term

Genes observed

Genes expected

Ration of enrichment

P-values ≤ 0.001

CC

axon

19

7.02

2.71

1.40E-05

 

basal lamina

9

2.67

3.37

3.68E-04

 

basement membrane

14

5.35

2.62

2.94E-04

 

collagen

14

5.01

2.79

1.26E-04

 

cytoskeleton

65

39.27

1.66

1.35E-05

 

extracellular matrix

7

1.84

3.81

6.34E-04

 

extracellular matrix (sensu Metazoa)

63

26.57

2.37

0.00E+00

 

muscle myosin complex

6

1.17

5.13

1.30E-04

 

postsynaptic membrane

18

7.85

2.29

3.20E-04

 

sarcolemma

8

2.17

3.68

3.47E-04

 

sarcoplasmic reticulum

6

1.34

4.49

4.44E-04

 

synapse

24

9.52

2.52

5.03E-06

 

synaptic vesicle

15

6.35

2.36

6.87E-04

 

synaptosome

12

4.51

2.66

6.69E-04

 

troponin complex

6

1.34

4.49

4.44E-04

BP

calcium ion transport

19

8.02

2.37

1.32E-04

 

cell adhesion

88

50.79

1.73

4.41E-08

 

cytoskeleton organization and biogenesis

29

14.54

1.99

1.09E-04

 

ion transport

62

42.11

1.47

7.54E-04

 

muscle contraction

24

8.86

2.71

1.03E-06

 

muscle development

21

9.19

2.29

1.10E-04

 

regulation of long-term neuronal synaptic plasticity

4

0.67

5.98

7.77E-04

 

regulation of muscle contraction

14

3.01

4.65

1.97E-08

 

striated muscle contraction

9

2.51

3.59

1.89E-04

 

synaptic transmission

32

15.87

2.02

3.87E-05

 

synaptogenesis

4

0.67

5.98

7.77E-04

MF

actin binding

41

24.39

1.68

3.61E-04

 

calcium ion binding

113

78.70

1.44

2.03E-05

 

creatine kinase activity

6

1.00

5.99

2.16E-05

 

extracellular matrix structural constituent

23

9.69

2.37

2.57E-05

 

extracellular matrix structural constituent conferring tensile strength

13

4.51

2.88

1.48E-04

 

ion channel activity

44

25.40

1.73

1.05E-04

 

kainate selective glutamate receptor activity

4

0.67

5.98

7.77E-04

 

motor activity

30

13.03

2.30

3.33E-06

 

protein binding

502

443.45

1.13

1.87E-04

 

structural constituent of cytoskeleton

29

13.70

2.12

3.17E-05

 

structural constituent of muscle

15

4.01

3.74

5.99E-07

 

structural molecule activity

64

37.76

1.69

6.88E-06