Table 6 Enriched KEGG pathways for switch-like genes identified in alternate modes of expression in diabetes. Enriched KEGG pathways are shown for bimodal genes that switch states between healthy tissue and type I and II diabetes (T1 and T2, respectively). Enrichment scores are the number of observed genes over the number of expected genes. P-values were computed using the hypergeometric distribution.
From: Switch-like genes populate cell communication pathways and are enriched for extracellular proteins
|  | Tissue | KEGG pathway | Genes observed | Genes expected | Ration of enrichment | P ≤ 0.01 |
|---|---|---|---|---|---|---|
| Â | Heart | --- | --- | --- | --- | --- |
T1 | Muscle | Antigen processing and presentation | 9 | 1.05 | 8.60 | 8.11E-07 |
| Â | Â | Cell communication | 7 | 1.58 | 4.43 | 9.89E-04 |
| Â | Â | Cell adhesion molecules (CAMs) | 8 | 1.73 | 4.63 | 3.19E-04 |
| Â | Â | ECM-receptor interaction | 7 | 1.18 | 5.95 | 1.60E-04 |
| Â | Â | Focal adhesion | 9 | 2.66 | 3.38 | 1.38E-03 |
| Â | Â | Leukocyte transendothelial migration | 8 | 1.58 | 5.06 | 1.72E-04 |
| Â | Â | Natural killer cell mediated cytotoxicity | 6 | 1.67 | 3.59 | 6.47E-03 |
| Â | Â | Type I diabetes mellitus | 5 | 0.77 | 6.48 | 9.67E-04 |
| Â | Pancreas | Benzoate degradation via hydroxylation | 1 | 0.01 | 101.01 | 9.86E-03 |
| Â | Â | Leukocyte transendothelial migration | 3 | 0.17 | 17.62 | 6.02E-04 |
| Â | Â | Tight junction | 2 | 0.15 | 13.12 | 9.92E-03 |
| Â | Peripheral blood | --- | --- | --- | --- | --- |
T2 | Adipose | --- | --- | --- | --- | --- |
| Â | Liver | PPAR signaling pathway | 2 | 0.15 | 13.47 | 9.52E-03 |
| Â | Muscle | Antigen processing and presentation | 8 | 1.05 | 7.64 | 8.42E-06 |
| Â | Â | Cell communication | 6 | 1.58 | 3.80 | 4.92E-03 |
| Â | Â | Cell adhesion molecules (CAMs) | 8 | 1.73 | 4.63 | 3.19E-04 |
| Â | Â | ECM-receptor interaction | 6 | 1.18 | 5.10 | 1.09E-03 |
| Â | Â | Leukocyte transendothelial migration | 8 | 1.58 | 5.06 | 1.72E-04 |
| Â | Â | Natural killer cell mediated cytotoxicity | 6 | 1.67 | 3.59 | 6.47E-03 |
| Â | Â | Type I diabetes mellitus | 5 | 0.77 | 6.48 | 9.67E-04 |
| Â | Pancreas | --- | --- | --- | --- | --- |