Meta-Analysis Approach identifies Candidate Genes and associated Molecular Networks for Type-2 Diabetes Mellitus

BMC Genomics

Table 5 Gene set enrichment of the most significant KEGG pathways.

Pathway ID	SigSet	Set	Sig	All	P-value	Q-value	Pathway description
path:mmu03320	13	69	213	15274	1.02E-11	1.37E-09	PPAR signaling pathway
path:mmu04920	12	73	213	15274	3.46E-10	1.66E-08	Adipocytokine signaling pathway
path:mmu04930	10	44	213	15274	3.69E-10	1.66E-08	Type II diabetes mellitus
path:mmu04910	13	128	213	15274	2.70E-08	9.09E-07	Insulin signaling pathway
path:mmu04612	6	38	213	15274	1.30E-05	0.000351	Antigen processing and presentation
path:mmu00280	6	44	213	15274	3.11E-05	0.000697	Valine, leucine and isoleucine deg.
path:mmu04610	7	67	213	15274	3.98E-05	0.000764	Complement and coagulation casc.

All are the genes under consideration, Sig the number of candidate genes, Set is the number of genes in the pathway under study and SigSet the overlap of genes in the pathway and the candidate genes. P-values were computed with the upper tail of the hypergeometric distribution indicating the probability of observing this overlap by chance. Q-values are the multiple testing corrected P-values [60, 61].

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