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Table 2 Checkpoint dependent and tissue specific induction of IR-induced genes.

From: Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

 

qRT-PCR

GeneChip

gene

N2 wild type

mrt-2(e2663)

cep-1 (lg12501)

N2 wild type

N2 wild type

cep-1 (lg12501)

    

germlines

embryos

  

F49F1.6

39.34

45.38

49.03

ND

2.43

155.32

98.58

dod-22

12.06

6.29

10.54

ND

ND

9.90

8.55

lys-2

5.28

5.28

5.43

5.46

5.66

3.52

3.00

pme-5

2.00

4.88

1.37

1.03

1.78

5.68

6.82

Y47G7B.2

2.39

1.68

-1.01

1.23

2.27

1.78

1.01

egl-1

3.93

1.89

-1.61

6.96

-6.19

2.39

-1.20

ced-13

81.43

2.99

-1.30

-1.43

21.86

1.73

1.00

  1. Quantitative RT-PCR was performed on samples taken 2 h after gamma-irradiation with 120 Gy. GeneChip refers to the Affymetrix GeneChip experiment using worms 2 h after X-ray treatment. Values correspond to fold changes.