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Table 4 Reporter Metabolite analysis

From: Transcription factor control of growth rate dependent genes in Saccharomyces cerevisiae: A three factor design

Reporter Metabolites

Number of neighbors

P-value

Orotate

3

7.10E-04

D-Mannose 6-phosphate

5

9.71E-04

Spermidine

3

1.68E-03

alpha, alpha-Trehalose

4

3.30E-03

5-Phospho-alpha-D-ribose 1-diphosphate

17

5.15E-03

1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide

4

5.22E-03

D-Ribose 5-phosphate

18

7.42E-03

Dolichyl beta-D-mannosyl phosphate

7

7.60E-03

FAD

2

9.45E-03

1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

3

9.99E-03

beta-D-Glucose

3

1.00E-02

ATP

113

1.02E-02

5'-Methylthioadenosine

2

1.05E-02

alpha-D-Glucose 6-phosphate

11

1.19E-02

O-Phospho-4-hydroxy-L-threonine

2

1.26E-02

N6-(L-1,3-Dicarboxypropyl)-L-lysine

2

1.37E-02

Glycogen

4

1.42E-02

Urea-1-carboxylate

1

1.69E-02

(S)-Dihydroorotate

2

1.75E-02

2-Phenylacetamide

1

1.82E-02

Phenylacetic acid

1

1.82E-02

Indole-3-acetamide

1

1.82E-02

Indole-3-acetate

1

1.82E-02

(S)-1-Pyrroline-5-carboxylate

1

1.82E-02

L-1-Pyrroline-3-hydroxy-5-carboxylate

1

1.82E-02

trans-4-Hydroxy-L-proline

1

1.82E-02

  1. Reporter Metabolite analysis [18] identifies metabolites around which the most significant transcriptional changes occur. The number of neighbors indicates the number of genes whose products catalyze a reaction involving that particular metabolite. The algorithm took as input the MAANOVA analysis referring to dilution rate effect. The P-value gives a measure of significance and all results < 0.02 are reported.