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Table 1 Gene ontology enrichment

From: Integrative analysis of RUNX1 downstream pathways and target genes

 

FPD

CBF

E8.5

E12

GO: Biological processes

Immune response p = 6.5 × 10 -5 36 genes

Macromolecular complex assembly p = 0.02 47 genes

Blood vessel development p = 0.06 15 genes

Response to external stimulus* p = 0.0003 18 genes

 

Negative regulation of apoptosis p = 0.002 16 genes

Cell growth p = 0.02 21 genes

 

Behavior p = 0.0003 14 genes

 

Response to biotic stimulus p = 0.002 19 genes

  

Immune system process p = 0.0006 18 genes

 

Cell proliferation p = 0.01 36 genes

   

GO: Molecular functions

Cadmium ion binding p = 0.002 4 genes

RNA binding p = 0.03 50 genes

 

IgG binding p = 0.006 3 genes

  

Cadmium ion binding p = 0.03 4 genes

 

Ferric-chelate reductase activity p = 0.03 2 genes

    

Polysaccharide binding p = 0.03 6 genes

GO: cellular component

 

Spindle p = 0.06 11 genes

Cell junction p = 0.06 14 genes

Cell surface p = 0.05 9 genes

    

Extracellular space p = 0.06 37 genes

InterPro motifs (FatiGo)

Vertebrate metallothionein p = 0.0001

Vertebrate metallothionein p = 0.02

  
  

Tubulin p = 0.04

  
  1. The most significant gene ontology annotations are indicated for each dataset as identified through GOStat in April 2007. InterPro motifs were identified through the FatiGo program. The p-values are corrected for multiple testing (False discovery rate, Benjamini).