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Figure 11 | BMC Genomics

Figure 11

From: Genome-wide analysis of CCCH zinc finger family in Arabidopsis and rice

Figure 11

Sequence alignments and the structure of AtC3H14 tandem domains in complex with the RNA. A, Alignment of AtC3H14, AtC3H15, OsC3H9, OsC3H39, hTTP and hTIS11d. Conserved motifs are highlighted in light blue, gold and red (cysteines and histidines involved in zinc binding, respectively), and green (aromatic residues involved in base-stacking interactions with RNA). h, Homo sapiens. B, Structure of the RNA complex of AtC3H14. This proposed structure was modelled on the original nuclear magnetic resonance structure describe by Hudson et al. [69], using their pdb coordinates and the Swiss-Model program. The RNA oligonucleotide is shown in magenta (A3 and A7 are shown in yellow) with the 5' and 3' ends indicated. The protein backbone are shown to represent the structure, with alpha helices are coloured royal blue, beta sheets are coloured yellow, the zinc-coordinating ligands are colored green and the zinc residues are coloured red. C, Molecular contact surface of AtC3H14 structure showing surface topology. Blue denotes convex surfaces. The location of the motifs that form the U6 and U2 binding pockets and the aromatic residues which are essential for high-affinity binding are indicated.

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