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Figure 1 | BMC Genomics

Figure 1

From: Evolution of the holozoan ribosome biogenesis regulon

Figure 1

E(CG) is a core promoter element of Drosophila ribosome biogenesis (RiBi) genes. (A) Fly RiBi genes (5 examples shown) generally possess three common features around the transcriptional start site (rightward pointing arrow) and upstream of the translational start (ATG). This distinct promoter architecture is characterized by a CG-core E-box (blue box), a specific E(CG) flanking motif (green box) and a coordinating cluster of sites matching the DNA Replication Element, DRE, (red boxes) spanning a distance less than 100 bp. The distance of E(CG) to the TSS for each gene is indicated above E(CG). G6375 corresponds to the pit gene, which is a known Myc target and an RiBi gene [18]. (B) This core promoter architecture identifies several functional groups of genes associated with RiBi (green circles). The number of genes is indicated for functional groups with more than 3 members. The sum of 151 genes (large circle) is the sum of all of the individual subfunctions with specific roles in Ribosome Biogenesis. The RiBi genes encode a variety of domains and protein folds including RNA-binding regions (RNP-1), C-terminal helicases, DEAD/DEAH box helicases, WD-40 repeats, ARM repeats, Histone-folds, AAA ATPases and many others [see Additional file 1]. (C) The results of genome queries in Drosophila for E(CG) type core promoters results in a highly significant enrichment of GO terms directly related to ribosome biogenesis (nucleolar, rRNA metabolism, rRNA binding, snoRNA complex, pseudouridine synthesis, ribosomal subunits, etc.)

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