Table 2 Gene expression fold change differences for the BTB-infected animal group (n = 8) between T3 and T0 validated using real time qRT-PCR.
Gene symbol | Gene name | Gene ontology (GO) function/s | Fold change difference | P-value |
|---|---|---|---|---|
IFNG | Interferon γ | Cytokine activity | +16.62 ± 8.74 | 0.0012 |
AKT1 | V-akt murine thymoma viral oncogene homolog 1 | Protein kinase activity | +4.12 ± 0.46 | 0.0000 |
IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | Transcription activator activity | +3.64 ± 0.61 | 0.0000 |
NCOR1 | Nuclear receptor co-repressor 1 | Transcriptional repression | +2.80 ± 0.46 | 0.0001 |
IL1RN | Interleukin 1 receptor antagonist | Signal transduction | +2.79 ± 0.60 | 0.0012 |
TOLLIP | Toll interacting protein | Signal transduction | +2.33 ± 0.34 | 0.0002 |
LTA | Lymphotoxin alpha (TNF superfamily, member 1) | Cytokine activity | +2.27 ± 0.75 | 0.0135 |
TLR4 | Toll-like receptor 4 | Bacterial binding and signal transduction | +2.24 ± 0.36 | 0.0037 |
MAPKAPK2 | Mitogen-activated protein kinase-activated protein kinase 2 | Signal transduction | +2.12 ± 0.28 | 0.0001 |
IL8 | Interleukin 8 | Cytokine activity | +2.09 ± 0.19 | 0.0000 |
IL1A | Interleukin 1α | Cytokine activity | +1.73 ± 0.22 | 0.0021 |
NFKB1 | Nuclear factor κβ | Transcriptional activation | +1.40 ± 0.42 | 0.0082 |
CHUK | Conserved helix-loop-helix ubiquitous kinase | Signal transduction | +1.38 ± 0.09 | 0.0009 |
TICAM2 | Toll-like receptor adaptor molecule 2 | Signal transduction | +1.28 ± 0.07 | 0.0006 |
IL10 | Interleukin 10 | Cytokine activity | +1.24 ± 0.09 | 0.0095 |
TGFB1 | Transforming growth factor, beta 1 | Protein binding | +1.19 ± 0.34 | 0.0021 |
TNF | Tumor necrosis factor (TNF superfamily, member 2) | Cytokine activity | +0.94 ± 0.48 | 0.0314 |
IL1R2 | Interleukin 1 receptor 2 | Cytokine activity | -1.56 ± 0.63 | 0.0012 |