Figure 4

Unrooted phylogenetic tree of an expanded set of LRRCE-containing sequences, including those from UniProt, NCBI and ENSEMBL databases. Sequences group themselves in four main SLRP classes, and the class II branch has been split into two subclasses IIa and IIb. See text for the abbreviations describing each SLRP type. The positions of several sequences specifically discussed in the text are indicated with bold-type numerals: 1, SLRP1 sequences from Ciona intestinalis and Ciona savignyi; 2, biglycan-like (BGL) and decorin-like (DCL) sequences from sea lamprey Petromyzon marinus; 3, keratocan-like (KERAL) sequence from lamprey; 4, epiphycan-like (EPYL) sequence from lamprey; 5, cluster of second copies of fibromodulin (FMOD2) exclusive to fish genomes; 6, cluster of second copies of lumican (LUM2) exclusive to fish genomes; 7, cluster of second copies of osteoglycin (OGN2) exclusive to fish genomes. This tree was calculated based on the sequence alignment of the LRRCE motifs. A larger version of this figure, with legible sequence names at the end of the phylogenetic tree branches, is provided as Additional File 2.