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Table 1 S. agalactiae genes that are differentially regulated in the mtaR mutant.

From: Global transcriptional profiling reveals Streptococcus agalactiae genes controlled by the MtaR transcription factor

Locus (gene)

Function/annotation/homology

P value

Fold change

Transport and binding proteins

SAN_1753 (metP)

ABC transporter, permease

4.4 × 10-6

-2.43

SAN_1754 (metN)

ABC transporter, ATP-binding

5.8 × 10-7

-2.43

SAN_1756 (metQ)

ABC transporter, substrate-binding

3.5 × 10-11

-5.30

SAN_0595 (artP)

ABC transporter, permease

2.5 × 10-7

-2.35

SAN_0596 (artQ)

ABC transporter, ATP-binding

9.7 × 10-6

-2.44

Protein fate: degradation of proteins, peptides, and glycopeptides

SAN_1755 (pdsM)

Peptidase, M20/M25/M40 family

2.1 × 10-9

-3.72

SAN_2186 (cspA)

Serine protease

2.3 × 10-7

-3.20

SAN_1255

Streptokinase-like

1.4 × 10-5

-2.65

Amino acid biosynthesis

SAN_0156 (argG)

Argininosuccinate synthase

8.6 × 10-5

-2.60

SAN_0157 (argH)

Argininosuccinate lyase

8.7 × 10-6

-2.91

Energy metabolism

SAN_0597 (manB)

Phosphomannomutase or Phosphoglucomutase

4.1 × 10-5

-2.04

Hypothetical conserved

SAN_0933

 

8.3 × 10-4

+2.47

  1. The differentially-regulated genes are grouped into functional categories, based on experimental evidence, protein database searches, and genome annotation. Each GBS COH1 gene [14] is indicated by its Comprehensive Microbial Resources locus number (SAN number) available on the J. Craig Venter Institute website http://www.jcvi.org/cms/research/projects/cmr/ and gene symbol, when applicable. Fold changes in gene expression (mtaR mutant relative to wild-type) and Bayesian P values were derived using Cyber-T [38] analysis of data from three independent biological replicates. Criteria for inclusion in this table were the following: Bayesian P value < 0.001, greater than two-fold change, and confirmation of differential expression by qPCR (Table 2).