Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages

BMC Genomics

Table 3 Common KEGG pathways enriched in the different expression datasets.

	K	L	J	R	W	St	Sc	Tot	Expr.
*Array platform type*	Membrane	cDNA	cDNA	cDNA	Affy	Affy	cDNA
*Muscle fibre composition*	fast	Mixed	mixed	fast	mixed	slow	mixed
*Organism*	RN	RN	MM	MM	HS	RN	RN
Energy Metabolism
Nitrogen metabolism		X	X	X	X	X	X	6	-
Carbon fixation		X	X	X	X	X	X	6	-
Crebb Cycle		X	X	X	X		X	5	-
Oxidative phosphorylation		X	X			X	X	4	-
Carbohydrate Metabolism
Glycolysis/Gluconeogenesis		X	X	X		X	X	5	-
Pyruvate metabolism		X	X		X	X	X	5
Citrate cycle (TCA cycle)		X	X	X	X		X	5
Pentose phosphate pathway		X		X		X	X	4	-
Glyoxylate and dicarboxylate metabolism		X	X		X		X	4
Butanoate metabolism		X	X			X	X	4
Amino Acid Metabolism
Cysteine metabolism	X	X		X		X	X	5
Phenylalanine, tyrosine and tryptophan biosynthesi		X	X	X		X	X	5
Valine, leucine and isoleucine degradation		X	X		X	X	X	5
Lysine degradation		X	X			X	X	4
Phenylalanine metabolism		X	X	X			X	4
Methionine metabolism	X	X	X		X			4
Urea cycle and metabolism of amino groups		X			X	X	X	4
Neurodegenerative Diseases
Neurodegenerative Disorders		X	X			X	X	4
Parkinson's disease		X	X	X			X	4
Alzheimer's disease	X		X			X	X	4
Other
Glutathione metabolism	X	X		X		X	X	5
Proteasome		X	X	X	X		X	5	+
Ribosome	X	X		X	X		X	5
Focal adhesion	X	X	X				X	4
Insulin signalling pathway		X	X	X			X	4
Complement and coagulation cascades		X		X	X	X		4

K: Kostrominova et al.; L: Lecker et al.; J: Jagoe at al.; R: Raffaello et al.; W: Welle et al.; St: Steavenson et al.; Sc: Sacheck et al. X indicates if the category is significantly enriched in the corresponding study (FDR < = 0.1). In the organism row: RN is Rattus Norvegicus, MM Mus Musculus, HS Homo Sapiens. The Expr column indicates the up (+) or down (-) regulation of genes belonging to each class. When the sign is not reported it means that gene belonging to that class are characterised by a mixed expression regulation.

ISSN: 1471-2164