Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages

BMC Genomics

Table 5 Over represented transcription factor binding sites shared by differentially expressed genes across the different atrophic states.

Up or down regulated genes	TFBS	Denervation	Fasting	Ageing	Diseases	Unloading	tot
-	SP1	X		X	X	X	4
-	MZF1_1–4	X		X	X	X	4
-	Myf	X	X		X		3
-	Roaz		X	X	X		3
-	deltaEF1	X		X	X		3
-	HAND1-TCF3			X	X		2
-	HNF4		X	X			2
-	MAX	X			X		2
-	MEF2A	X	X				2
-	NHLH1	X			X		2
-	PPARG		X		X		2
-	REL			X		X	2
-	RELA			X		X	2
-	SRF		X			X	2
-	TEAD	X				X	2
-	ZNF42_5–13			X		X	2
-	Arnt-Ahr			X			1
-	ELK4		X				1
-	Hox11-CTF1		X				1
-	MYC-MAX	X					1
-	Myb				X		1
-	NF-kappaB					X	1
-	NFKB1	X					1
-	NR2F1		X				1
-	RREB1		X				1
-	Spz1					X	1
-	TCF1					X	1
+	NHLH1	X	X			X	3
+	Staf		X	X	X		3
+	TEAD	X	X	X			3
+	ZNF42_1–4	X	X			X	3
+	Ar		X		X		2
+	E2F1		X			X	2
+	ELK4		X		X		2
+	MAX		X		X		2
+	Pax4			X	X		2
+	RREB1			X	X		2
+	SP1	X				X	2
+	deltaEF1	X				X	2
+	Arnt-Ahr					X	1
+	Bapx1			X			1
+	CREB1		X				1
+	ELK1		X				1
+	ESR1			X			1
+	FOXD1				X		1
+	FOXF2				X		1
+	Foxq1				X		1
+	HLF			X			1
+	Hox11-CTF1	X					1
+	IRF2	X					1
+	MEF2A			X			1
+	MYC-MAX	X					1
+	Myb	X					1
+	NFIL3			X			1
+	NFKB1					X	1
+	RELA					X	1
+	RORA1					X	1
+	RXR-VDR				X		1
+	SRF			X			1
+	TP53	X					1
+	ZNF42_5–13					X	1

X indicates if the specific TFBS category is significantly enriched in that specific study. (-) TFBS enriched in the up/downstream regions of down-regulated genes; (+) TFBS enriched in the up/downstream regions of up-regulated genes

ISSN: 1471-2164