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Table 1 Average response to LPS from young and old cultures as measured by increase in expression of immune associated genes as compared to hour 0 post-LPS

From: Age dependent changes in the LPS induced transcriptome of bovine dermal fibroblasts occurs without major changes in the methylome

Gene symbol

Gene name

Fold change*

  

Hour 2

Hour 8

Transcription and activation pathways

  

BIRC3

Baculoviral IAP repeat-containing protein 3

6.1

4.1

NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

36.1

10

NFKBIZ

Nuclear factor of kappa-B inhibitor zeta

23.8

4.1

NFKB2

Nuclear factor of κ light polypeptide gene enhancer in B-cells 2

2

2.1

Cytokines and chemokines, growth factors

 

CCL2

Chemokine (C-C motif) ligand 2

28.5

26.7

CCL5

RANTES

35.4

48.4

CCL20

Chemokine (C-C motif) ligand 20

2034

1162.3

CSF2

Colony stimulating factor 2

97

6.1

CXCL1

Chemokine (C-X-C motif) ligand 1

2.5

- -

CXCL2

Chemokine (C-X-C motif) ligand 2

43.8

27.1

CXCL5

Chemokine (C-X-C motif) ligand 5

43.8

27.1

IFNB

Interferon beta precursor

2

2

IL1A

Interleukin 1, alpha

86.0

23.5

IL-6

Interleukin 6

83

131.6

IL-8

Interleukin 8

123.7

273.7

SAA3

Serum Amyloid A 3

505.6

2498.3

TNF-a

Tumor Necrosis Factor, alpha

125.2

- -

TNFSF13B

Tumor necrosis factor (ligand) superfamily, member 13 (BAFF)

- -

4.6

Type I IFN-related genes

  

IFI44

Similar to Interferon-induced protein 44

- -

15.2

IFIH1

Interferon induced with helicase C domain 1

- -

15.1

ISG15

ubiquitin-like modifier

6.2

63.2

MX2

Myxovirus (influenza virus) resistance 2

- -

121.2

OAS1

2′-5′-oligoadenylate synthetase 1

- -

24.6

OAS2

2′-5′-oligoadenylate synthetase 2

2.8

26.1

TNFSF10

Tumor necrosis factor ligand superfamily member 10 (TRAIL)

- -

15.8

  1. *Data obtained by RNA-Seq and presented as fold induction of the indicated gene at either 2 or 8 hours post-LPS in comparison to expression levels at 0 hours post-LPS. All fold changes shown are FDR < 0.05; FC > 2; and CPM >1. - - indicates FDR > 0.05, FC < 2, or CPM < 1.