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Figure 1 | BMC Genomics

Figure 1

From: Pervasive and opposing effects of Unpredictable Chronic Mild Stress (UCMS) on hippocampal gene expression in BALB/cJ and C57BL/6J mouse strains

Figure 1

Principal components analysis. Plotting the scores following Pareto scaling shows that the first unrotated principal component of variance can be interpreted as mouse strain. There is a wide separation between C57BL/6J (triangles) and BALB/cJ (circles) but this is expected as different strains reflect a different genetic panel. A compelling result is the separation of samples by treatment in the second component. There are striking differences between the two strains in response to UCMS at this is clearly visible at the genomic level. Additionally, the results show that the direction of the UCMS effect is in opposing direction in C57BL/6J and BALB/6.

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BMC Genomics

ISSN: 1471-2164

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