Figure 2
From: Genome-wide co-occupancy of AML1-ETO and N-CoR defines the t(8;21) AML signature in leukemic cells
AML1-ETO and N-CoR peaks relate to similar gene ontology terms and motifs discovered de novo. (A) Gene ontology was used to infer biologically relevant pathways among ChIP-seq libraries using highly-ranked peaks (p < 10−75 from MACS). Shown are top-ranked gene ontology terms within Biological Process (A) and Molecular Signatures Database Perturbation (B) [64]. Values on column plots represent –log10(binomial p-value) computed using GREAT (version 2.0.2) [35] with the default association rules. Note: some ontology term names were shortened. (C) HOMER de novo motif analysis [54] of AML1, AML1-ETO, N-CoR, and p300 libraries. Displayed are the top-ranked motifs for each library with log(p-value) scores. Genomic loci occupied by AML1, the fusion protein and N-CoR were enriched in the Runx1 motif. Candidate transcription factors that harbor these motifs (listed in the ranked list of motif results) are shown in parentheses.