Table 1 Relationships between recurrence-associated pathways and clinicopathological variables in HBV-HCC

Gender (Male/Female)

52/14

65/11

0.406

0.563 (0.320 0.991)

0.0439

Age (<50 y/≥50 y)

26/40

27/49

0.763

1.056 (0.706 1.577)

0.790

Platelet (<170 × 10⁹/L/≥170 × 10⁹/L)

33/25

28/36

0.204

1.019 (0.675 1.538)

0.928

⁴AST (<40 IU/L/≥40 IU/L)

40/26

31/45

0.0287

1.096 (0.745 1.613)

0.639

⁴ALT (<40 IU/L/≥40 IU/L)

41/25

33/43

0.0397

1.003 (0.682 1.477)

0.984

Bilirubin (<1 mg/dL/≥1 mg/dL)

44/22

42/34

0.224

1.050 (0.708 1.556)

0.806

⁴AFP (<300 ng/mL /≥300 ng/mL)

41/25

52/23

0.469

0.976 (0.644 1.480)

0.912

Child-Pugh (A/B,C)

63/3

65/10

0.131

1.813 (0.967 3.401)

0.0596

UICC (I,II/III,IV)

39/25

50/22

0.389

1.519 (1.015 2.273)

0.0404

Size (<3 cm/≥3 cm)

14/52

12/64

0.538

2.178 (1.216 3.901)

0.00726

Number (Single/Multiple)

56/10

64/10

0.972

1.874 (1.135 3.094)

0.0125

Necrosis (No/Yes)

33/33

25/50

0.0664

1.565 (1.048 2.339)

0.0273

Edmondson’s grade (I,II/III,IV)

45/19

45/27

0.435

1.273 (0.974 1.665)

0.0764

Vein invasion (Absent/Present)

49/12

39/31

0.00501

1.787 (1.175 2.718)

0.00594

Lobular activity (No/Yes)

39/25

18/56

2.879 × 10 ⁻⁵

1.770 (1.166 2.685)

0.00652

Capsule (Absent/Present)

47/19

64/11

0.0660

0.617 (0.374 1.017)

0.05603

Margin (<2 cm/≥2 cm)

35/31

51/23

0.0794

0.836 (0.557 1.256)

0.389

Cirrhosis (Absent/Present)

37/29

41/34

0.997

1.257 (0.853 1.852)

0.245

Recurrence-associated pathways

-

-

-

2.843 (1.881 4.295)

2.416 × 10 ⁻⁷

Multivariate analysis

Recurrence-associated pathways

3.220 (2.076 4.994)

1.760 × 10 ⁻⁷

Number (Single/Multiple)

1.839 (1.095 3.089)

0.0212

Size (<3 cm/≥3 cm)

2.489 (1.288 4.808)

0.00666

Edmondson’s grade (I,II/III,IV)

1.769 (1.159 2.701)

0.00821