Figure 3
From: Characterization and identification of hidden rare variants in the human genome
Network of TCGA driver genes containing RRA loci in GRCh37. To build the network we selected all the interactions of HumanNet v1 that link the 291 TCGA driver genes [41]. Node colors represent the most severe RRA variant contained by each gene: none RRA (white), non-exonic (grey), synonymous (orange), splicing (red) and missense RRA (magenta). Node border colors represent the TCGA cancer type for which the gene has been predicted to be a driver with maximum mutation frequency: AML (Acute Myeloid Leukemia), BLCA (Bladder Urothelial Carcinoma), BRCA (Breast invasive carcinoma), COAD (Colon adenocarcinoma), GBM (Glioblastoma multiforme), HNSC (Head and Neck squamous cell carcinoma), KIRC (Kidney renal clear cell carcinoma), LUAD (Lung adenocarcinoma), LUSC (Lung squamous cell carcinoma), OV (Ovarian serous cystadenocarcinoma), UCEC (Uterine Corpus Endometrial Carcinoma), UVM (Uveal Melanoma). Node radius gives a measure of the maximum mutation frequency of the driver gene in the TCGA cancer dataset coded by the border color.