Parameter | Dependent variable: half-life | |||||||
---|---|---|---|---|---|---|---|---|
μ = 0.10 h −1 | μ = 0.20 h −1 | μ = 0.40 h −1 | μ = 0.63 h −1 | |||||
Est. Coeff. | P-value | Est. Coeff. | P-value | Est. Coeff. | P-value | Est. Coeff. | P-value | |
[mRNA] | −0.91 | <10 −226 | −0.80 | 1.4E10 −223 | −0.80 | 2.9E10 −225 | −0.79 | 4.3E10 −205 |
CAI | 0.13 | 2.6E10 −15 | 0.18 | 1.7E10 −15 | 0.18 | 5.5E10 −17 | 0.25 | 7.9E10 −28 |
ORF length | −0.14 | 2.8E10 −5 | −0.16 | 2.2E10 −4 | −0.19 | 1.1E10 −5 | −0.12 | 7.7E10 −3 |
5UTR + ORF length | 0.05 | 9.4E10 −2 | 0.06 | 1.3E10 −1 | 0.14 | 9.1E10 −4 | 0.09 | 5.2E10 −2 |
5’UTR + ORF GC% | −0.05 | 4.4E10 −4 | −0.07 | 3.1E10 −4 | −0.10 | 1.3E10 −7 | −0.09 | 8.0E10 −6 |
Essential genes | 0.06 | 8.1E10 −3 | 0.12 | 4.4E10 −5 | 0.10 | 2.7E10 −4 | 0.06 | 4.5E10 −2 |
No. of genes in operon | ||||||||
1 | 0.29 | 2.3E10 −1 | 0.55 | 8.1E10 −2 | 0.46 | 1.4E10 −1 | 0.43 | 2.0E10 −1 |
2 | −0.15 | 2.4E10 −3 | −0.16 | 1.1E10 −2 | −0.29 | 3.8E10 −6 | −0.09 | 1.7E10 −1 |
3 | −0.16 | 1.3E10 −3 | −0.21 | 2.0E10 −3 | −0.31 | 2.3E10 −6 | −0.16 | 2.1E10 −2 |
4 | −0.10 | 8.2E10 −2 | −0.10 | 1.9E10 −1 | −0.19 | 9.0E10 −3 | −0.11 | 1.5E10 −1 |
5 | −0.02 | 7.8E10 −1 | −0.06 | 4.3E10 −1 | −0.14 | 8.1E10 −2 | −0.06 | 4.6E10 −1 |
6 | −0.14 | 3.2E10 −2 | −0.09 | 3.1E10 −1 | −0.12 | 1.6E10 −1 | −0.11 | 2.2E10 −1 |
7 | 0.03 | 7.1E10 −1 | 0.08 | 4.0E10 −1 | 0.06 | 5.4E10 −1 | 0.08 | 4.3E10 −1 |
8 | −0.07 | 6.3E10 −1 | −0.07 | 6.9E10 −1 | −0.04 | 8.3E10 −1 | −0.01 | 9.4E10 −1 |
9 | −0.08 | 3.9E10 −1 | 0.04 | 7.2E10 −1 | 0.04 | 7.4E10 −1 | −0.03 | 8.3E10 −1 |
10 | −0.13 | 3.1E10 −1 | −0.11 | 5.2E10 −1 | −0.10 | 5.1E10 −1 | 0.05 | 7.5E10 −1 |
11 | −0.29 | 4.1E10 −1 | −0.52 | 2.4E10 −1 | −0.43 | 3.3E10 −1 | −0.65 | 1.7E10 −1 |
12 | 0.45 | 3.3E10 −4 | 0.50 | 2.2E10 −3 | 0.74 | 4.0E10 −6 | 0.84 | 1.3E10 −6 |
13 | 0.48 | 1.8E10 −4 | 0.49 | 3.3E10 −3 | 0.59 | 2.9E10 −4 | 0.31 | 8.1E10 −2 |
16 | −0.12 | 6.2E10 −1 | −0.36 | 2.6E10 −1 | −0.28 | 3.7E10 −1 | −0.48 | 1.6E10 −1 |
COG annotation | ||||||||
[C] | −0.00 | 1.0E10 −0 | 0.02 | 8.8E10 −1 | 0.05 | 7.5E10 −1 | −0.01 | 9.3E10 −1 |
[D] | 0.39 | 8.2E10 −13 | 0.53 | 5.8E10 −14 | 0.59 | 6.2E10 −18 | 0.54 | 1.3E10 −13 |
[E] | −0.21 | 6.5E10 −2 | −0.23 | 1.3E10 −1 | −0.23 | 1.2E10 −1 | −0.41 | 1.0E10 −2 |
[F] | 0.01 | 8.4E10 −1 | 0.05 | 3.1E10 −1 | 0.06 | 2.7E10 −1 | 0.23 | 1.8E10 −5 |
[G] | −0.13 | 6.6E10 −2 | −0.16 | 7.5E10 −2 | −0.16 | 8.4E10 −2 | 0.24 | 1.4E10 −2 |
[H] | 0.12 | 2.0E10 −2 | 0.20 | 4.7E10 −3 | 0.20 | 3.6E10 −3 | 0.14 | 6.3E10 −2 |
[I] | −0.12 | 4.4E10 −2 | −0.18 | 1.7E10 −2 | −0.24 | 1.4E10 −3 | −0.22 | 6.1E10 −3 |
[J] | 0.20 | 6.2E10 −3 | 0.21 | 2.6E10 −2 | 0.23 | 1.3E10 −2 | 0.31 | 2.4E10 −3 |
[K] | 0.10 | 7.2E10 −2 | 0.04 | 5.5E10 −1 | 0.06 | 3.8E10 −1 | −0.03 | 6.8E10 −1 |
[L] | −0.01 | 8.4E10 −1 | −0.05 | 4.4E10 −1 | −0.07 | 2.7E10 −1 | −0.12 | 6.6E10 −2 |
[M] | 0.13 | 2.4E10 −2 | 0.11 | 1.6E10 −1 | 0.02 | 7.5E10 −1 | −0.02 | 8.3E10 −1 |
[N] | −0.12 | 3.3E10 −2 | −0.15 | 4.3E10 −2 | −0.14 | 3.6E10 −2 | −0.11 | 1.3E10 −1 |
[O] | 0.16 | 3.0E10 −1 | 0.25 | 2.0E10 −1 | 0.25 | 1.9E10 −1 | 0.28 | 1.7E10 −1 |
[P] | −0.10 | 8.7E10 −1 | −0.12 | 1.1E10 −1 | −0.11 | 1.5E10 −1 | −0.13 | 1.2E10 −1 |
[Q] | −0.19 | 2.4E10 −3 | −0.25 | 2.2E10 −3 | −0.19 | 1.5E10 −2 | −0.12 | 1.5E10 −1 |
[R] | −0.08 | 5.4E10 −1 | −0.12 | 4.6E10 −1 | −0.20 | 2.2E10 −1 | −0.16 | 3.5E10 −1 |
[S] | 0.01 | 8.8E10 −1 | −0.01 | 8.0E10 −1 | −0.04 | 4.9E10 −1 | −0.03 | 6.1E10 −1 |
[T] | −0.10 | 2.7E10 −2 | −0.12 | 5.4E10 −2 | −0.10 | 1.1E10 −1 | −0.12 | 5.5E10 −2 |
[U] | 0.15 | 4.2E10 −2 | 0.21 | 2.6E10 −2 | 0.30 | 1.3E10 −3 | 0.05 | 5.9E10 −1 |
[V] | −0.19 | 9.8E10 −2 | −0.22 | 1.4E10 −1 | −0.29 | 4.8E10 −2 | −0.31 | 5.0E10 −2 |
Cell location | ||||||||
Cytoplasmic | −0.07 | 4.0E10 −1 | −0.08 | 4.3E10 −1 | N.S | N.S | ||
Inn. Mb. Lipo. | −0.12 | 1.1E10 −1 | −0.11 | 2.6E10 −1 | N.S | N.S | ||
Int. Mb. Pr. | −0.20 | 3.9E10 −1 | −0.27 | 3.8E10 −1 | N.S | N.S | ||
Mb. Anchored | 0.04 | 6.3E10 −1 | 0.02 | 8.6E10 −1 | N.S | N.S | ||
Mb. Lipo. | −0.04 | 6.6E10 −1 | −0.11 | 3.4E10 −1 | N.S | N.S | ||
Out. Mb. B-Bar Pr. | 0.48 | 1.4E10 −1 | 0.55 | 1.9E10 −1 | N.S | N.S | ||
Out. Mb. Lipo. | 0.34 | 3.7E10 −2 | 0.48 | 2.4E10 −2 | N.S | N.S | ||
Periplasmic | −0.20 | 7.4E10 −1 | −0.21 | 1.5E10 −1 | N.S | N.S | ||
Unknown | −0.23 | 3.8E10 −2 | −0.27 | 1.0E10 −2 | N.S | N.S | ||
Peptide signal | −0.09 | 5.4E10 −2 | −0.12 | 5.8E10 −2 | N.S | N.S | ||
Adjusted R 2 | 0.74 | 0.56 | 0.57 | 0.51 |