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Table 3 Activated canonical pathways in LP-C comparisons

From: Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN

Ingenuity canonical pathways

-log(p-value)

Ratio

Granulocyte Adhesion and Diapedesis

19.60

0.31

Agranulocyte Adhesion and Diapedesis

12.20

0.25

Role of IL-17A in Psoriasis

10.10

0.79

Atherosclerosis Signaling

9.75

0.25

Pathogenesis of Multiple Sclerosis

9.73

0.90

Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

9.54

0.61

Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

8.91

0.67

Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza

8.38

0.39

LXR/RXR Activation

6.29

0.20

Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

6.13

0.22

Role of Cytokines in Mediating Communication between Immune Cells

5.89

0.31

Altered T Cell and B Cell Signaling in Rheumatoid Arthritis

5.85

0.22

T Helper Cell Differentiation

5.66

0.26

Hepatic Fibrosis / Hepatic Stellate Cell Activation

5.03

0.18

Communication between Innate and Adaptive Immune Cells

4.86

0.19

IL-10 Signaling

3.95

0.21

  1. Differentially expressed genes were used as a “signature” to find what biological function is changed in the skin of psoriasis patients.