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Figure 3 | BMC Genomics

Figure 3

From: MicroRNAs enrichment in GWAS of complex human phenotypes

Figure 3

Independent study replication confirms enrichment in Crohn’s Disease. Shown are plots of (A) stratified true discovery rate (TDR) and (B) cumulative replication rate as functions of the negative decadic logarithm of the p-value. The p-value in the cumulative replication rate plot refers to the p-value in the discovery sample. Replication is intended as achieved for p-value smaller than 0.05 in the replication sample. It is evident from (B) how, given a p-value threshold, miRNA associations replicate at a higher rate in independent samples than just any SNPs or SNPs in intergenic regions. The vertical intercept is the overall replication rate per category. The cumulative replication rate mirrors the TDR as should be expected.

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