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Figure 6 | BMC Genomics

Figure 6

From: The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress

Figure 6

The distribution patterns of HSC3 in Optiprep density gradient factions acquired from the HTorAΔE-expressing brains were different from those of the HTorAWT-expressing brains. (A) HSC3 was present in fraction Nos. 9–12 in the HTorAWT-expressing brains, with the strongest signals in fraction No. 11. However, HSC3 was detected from fraction Nos. 8–12 in the HTorAΔE-expressing brains with the strongest signals found in fraction No. 10. (B ~ E) Proteins identified from fraction 9 (B), 10(C), 11(D), and 12(E) from the HTorAΔE-expressing brains were different from those form the HTorAWT-expressing brains. (F) When all proteins identified from Faction 9 to 12 were pooled, fractions from HTorAΔE-expressing brains had 56 genes that were increased or unique, whereas 18 genes were increased or unique from the HTorAWT-expressing brains. Gene ontology profiles for functions (F) and pathways (G) were displayed, respectively.

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