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Table 2 The summary of Kaplan-Meyer survival analysis with altered expression of UPR sensor and inducers in HTorA ΔE -expressing flies

From: The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress

Genotype

p -value 1

Hazard ratio (95% CI) 2

Control

Trial

A

C155-Gal4/+;UAS-HTor1AΔE/+

C155-Gal4/+; UAS-HSC3-RNAi/UAS-HTor1AΔE

<0.001

6.579 (4.726, 9.159)

C155-Gal4/+;UAS-HSC3-RNAi/+

<0.001

8.135 (5.87, 11.27)

B

C155-Gal4/+;UAS-HTor1AΔE/+

C155-Gal4/+;UAS-HTor1AΔΕ/UAS-Xbp1-RNAi

<0.001

6.796 (4.865, 9.492)

C155-Gal4/+;UAS-HTor1AΔΕ/xbp1K13803

<0.001

21.23 (13.19, 34.17)

C155-Gal4/+; UAS-Xbp1-RNAi

C155-Gal4/+;UAS-HTor1AΔΕ/UAS-Xbp1-RNAi

<0.001

5.871 (4,351, 7.924)

C155-Gal4/+; xbp1K13803/+

C155-Gal4/+;UAS-HTor1AΔΕ/xbp1K13803

<0.001

15.42 (10.38, 22.9)

C

C155-Gal4/+;UAS-HTor1AΔE/+

C155-Gal4/+;UAS-HTor1AΔE/UAS-ATF6-RNAi

<0.001

2.222 (1.672, 2.954)

C155-Gal4/+;UAS-ATF6-RNAi/+

<0.001

1.976 (1.562, 2.499)

D

C155-Gal4/+;UAS-HTor1AΔE/+

C155-Gal4/+;UAS-HTor1AΔE/UAS-Pek-RNAi

<0.001

2.914 (2.158, 3.934)

C155-Gal4/+;UAS-Pek-RNAi/+

<0.001

7.408 (5.368, 10.22)

  1. 1 p-values were calculated using the log-rank test.
  2. 2Hazard ratios and its 95% confidential intervals (CI) were estimated using cox-regression.