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Figure 6 | BMC Genomics

Figure 6

From: High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field

Figure 6

Altered canonical pathways. A549 cells (n = 3) were exposed for 24 h and 72 h to increasing concentrations of fumed silica AEROSIL® 200 NPs (3.0 and 6.0 μg/cm2). Seven relevant canonical pathways disturbed after 24 h and 72 h exposure with two doses of NPs (3.0 and 6.0 μg/cm2) were revealed with the Ingenuity Pathway Analysis tool. Each canonical pathway is constituted of a finite number of genes. For each dose and time point, we calculated a ratio indicating the percentage of altered genes in our dataset belonging to a given canonical pathway. These pathways are all significant according to a Fisher statistical test (p-value < 0.05).

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