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Table 1 Significantly enriched Gene Ontology terms among co-expression network modules in CD14+ monocytes

From: Transcriptomic profiles of aging in purified human immune cells

Gene Ontology term

Gene Count

Direction of age effect

Fold Enrichment

Nominal P-value

FDR

‘Blue’ network module ( 217 genes; 217↓0↑)

Ribonucleoprotein complex:

58

(58↓0↑)

5.6

5.71E-29

7.40E-26

Translation

41

(41↓0↑)

6.9

3.48E-23

5.20E-20

Ribosome biogenesis

16

(16↓0↑)

7.1

4.57E-09

6.84E-06

RNA processing

26

(26↓0↑)

2.8

5.25E-06

7.86E-03

Mitochondrion:

61

(61↓0↑)

3.2

5.67E-18

7.36E-15

Oxidative phosphorylation

15

(15↓0↑)

10.0

1.57E-10

2.35E-07

Respiratory chain complex I

8

(8↓0↑)

11.3

4.55E-06

5.90E-03

‘ Turquoise’ network module (1,466 genes; 501↓965↑)

Nuclear lumen:

199

(48↓151↑)

1.4

9.05E-07

1.32E-03

RNA splicing

59

(17↓42↑)

1.8

1.43E-05

2.54E-02

  1. Results from gene set enrichment analysis are presented (from DAVID) for co-expression network modules with significantly enriched Gene Ontology (GO) terms (FDR < 0.05). No significant enrichment was observed among the ‘black’, ‘brown’, ‘yellow’, or ‘green’ network module genes; background genes included all 10,898 genes with expression detectable in 1,264 CD14+ monocyte samples.
  2. ↑ genes with expression positively associated with age; ↓ genes with expression negatively associated with age.
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BMC Genomics

ISSN: 1471-2164

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